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Effect of the character of ring fusion on the basicity of bicyclic hydrazides

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

The ionization constants of a number of 1,2-diazabicyclo-3-alkanones were measured. It was found that the basicity of 2-aza-3-quinuclidones is 1.5–2 orders of magnitude lower than in the remaining compounds. An assumption was made regarding the substantial effect of the character of ring fusion on the basicity of bicyclic hydrazides.

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Literature cited

  1. E. E. Mikhlina, N. A. Komarova, and M. V. Rubtsov, Khim. Geterotsikl. Soedin., 851 (1969).

  2. E. E. Mikhlina, N. A. Komarova, and M. V. Rubtsov, Khim. Geterotsikl. Soedin., 91 (1966).

  3. E. E. Mikhlina, N. A. Komarova, and M. V. Rubtsov, Khim. Geterotsikl. Soedin., 259 (1966).

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Authors and Affiliations

  1. S. Ordzhanikidze All-Union Scientific-Research Institute of Pharmaceutical Chemistry, Moscow

    L. N. Yakhontov, M. A. Portnov, E. E. Mikhlina, M. N. Vaisman & N. A. Komarova

Authors
  1. L. N. Yakhontov
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  2. M. A. Portnov
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  3. E. E. Mikhlina
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  4. M. N. Vaisman
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  5. N. A. Komarova
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Additional information

Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 2, pp. 220–221, February, 1972.

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Yakhontov, L.N., Portnov, M.A., Mikhlina, E.E. et al. Effect of the character of ring fusion on the basicity of bicyclic hydrazides. Chem Heterocycl Compd 8, 197–198 (1972). https://doi.org/10.1007/BF00472358

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  • DOI: https://doi.org/10.1007/BF00472358

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