Abstract
Bromination of 2-aryloxazolo[3,2-flxanthines gives the 3-bromoderivatives whereas 8-methyl-2-phenyloxazolo[3,2-f]xanthine is nitrated in the para-position of the phenyl substituent. Alkylation of oxazolo[3,2-f]xanthines by ethylmonoiodoacetate gives the ethyl esters of oxazolo[3,2-f]xanthinyl-6-acetic acids. Reaction of oxazolo[3,2-f]xanthines with sodium sulfide gives thiazolo[3,2-f]xanthines whereas the reaction with secondary amines opens the oxazole ring.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 10, pp. 1396–1399, October, 1990.
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Garmash, S.N., Skul'skaya, E.A., Priimenko, B.A. et al. Electrophilic and nucleophilic substitution in oxazolo[3,2-f]xanthines. Chem Heterocycl Compd 26, 1164–1167 (1990). https://doi.org/10.1007/BF00472193
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DOI: https://doi.org/10.1007/BF00472193