Chemistry of Heterocyclic Compounds

, Volume 10, Issue 9, pp 1029–1031 | Cite as

Competitive methylation of some phenolic compounds

  • Z. D. Kirsanova
  • V. A. Zagorevskii
  • D. A. Zykov


The competitive methylation of a mixture of 6-hydroxy-4-methylcoumarin and of 7-hydroxy-4-methylcoumarin and also of other compounds of phenolic nature has been studied. It had ben shown that in the presence of 1 mole of alkali, methylation of the more acidic hydroxyl takes place at the oxygen atom, and with 2 moles of alkali, the stronger conjugated base reacts.


Oxygen Methylation Hydroxyl Organic Chemistry Oxygen Atom 
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Copyright information

© Plenum Publishing Corporation 1976

Authors and Affiliations

  • Z. D. Kirsanova
    • 1
  • V. A. Zagorevskii
    • 1
  • D. A. Zykov
    • 1
  1. 1.Institute of PharmacologyAcademy of Medical Sciences of the USSRMoscow

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