Abstract
The reaction of benzoxazoles with aromatic and aliphatic acids, which gives transcyclization products — 2-substituted benzoxazoles — was studied. The reaction of 2-hydroxyacetanilide with aliphatic acids gives a mixture of 2-substituted benzoxazoles. Under similar conditions, 2-methylbenzothiazole, 2-alkyl-Δ2-oxazolines, and 2-alkyl-Δ2-thiazolines do not undergo transcyclization, but ring opening is observed in the latter two cases.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 11, pp. 1480–1482, November, 1972.
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Belyaev, E.Y., Kondrat'eva, L.E., Sandakov, V.B. et al. Transcyclization of benzoxazoles. Chem Heterocycl Compd 8, 1335–1337 (1972). https://doi.org/10.1007/BF00471865
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DOI: https://doi.org/10.1007/BF00471865