Chemistry of Heterocyclic Compounds

, Volume 14, Issue 7, pp 742–745 | Cite as

Friedel-Crafts alkylation of indoles

  • V. A. Budylin
  • M. S. Ermolenko
  • A. N. Kost


The alkylation of indole and 2-methylindole with alkyl halides in the presence of a complex catalyst — dipyridinezinc chloride — was investigated. Nitromethane was used as the solvent. 3-Alkylindoles were obtained in 30–80% yields in all cases. The reaction mechanism is discussed. Data from the PMR and mass spectra are presented.


Chloride Mass Spectrum Organic Chemistry Indole Reaction Mechanism 
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Copyright information

© Plenum Publishing Corporation 1979

Authors and Affiliations

  • V. A. Budylin
    • 1
  • M. S. Ermolenko
    • 1
  • A. N. Kost
    • 1
  1. 1.M. V. Lomonosov Moscow State UniversityMoscow

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