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Chemistry of Heterocyclic Compounds

, Volume 14, Issue 7, pp 742–745 | Cite as

Friedel-Crafts alkylation of indoles

  • V. A. Budylin
  • M. S. Ermolenko
  • A. N. Kost
Article

Abstract

The alkylation of indole and 2-methylindole with alkyl halides in the presence of a complex catalyst — dipyridinezinc chloride — was investigated. Nitromethane was used as the solvent. 3-Alkylindoles were obtained in 30–80% yields in all cases. The reaction mechanism is discussed. Data from the PMR and mass spectra are presented.

Keywords

Chloride Mass Spectrum Organic Chemistry Indole Reaction Mechanism 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Publishing Corporation 1979

Authors and Affiliations

  • V. A. Budylin
    • 1
  • M. S. Ermolenko
    • 1
  • A. N. Kost
    • 1
  1. 1.M. V. Lomonosov Moscow State UniversityMoscow

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