Chemistry of Heterocyclic Compounds

, Volume 9, Issue 7, pp 917–921 | Cite as

Synthesis of 4-thiouridine derivatives

  • L. I. Kolobushkina
  • A. M. Kritsyn
  • V. L. Florent'ev


The thionation of a protected uridine with the aid of P2S5 has given the corresponding 4-thiouridine derivatives, which have been phosphorylated at the 5′ or the 2′(3′)hydroxyl. On being heated in aqueous pyridine solution with liquid hydrogen sulfide, cytidine phosphates also form 4-thiouridine phosphates. 4-Thiouridine 2′,3′-cyclophosphate has been obtained.


Hydrogen Phosphate Sulfide Hydroxyl Organic Chemistry 
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Copyright information

© Plenum Publishing Corporation 1975

Authors and Affiliations

  • L. I. Kolobushkina
    • 1
  • A. M. Kritsyn
    • 1
  • V. L. Florent'ev
    • 1
  1. 1.Institute of Molecular BiologyAcademy of Sciences of the USSRMoscow

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