Abstract
The thionation of a protected uridine with the aid of P2S5 has given the corresponding 4-thiouridine derivatives, which have been phosphorylated at the 5′ or the 2′(3′)hydroxyl. On being heated in aqueous pyridine solution with liquid hydrogen sulfide, cytidine phosphates also form 4-thiouridine phosphates. 4-Thiouridine 2′,3′-cyclophosphate has been obtained.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 7, pp. 996–1000, July, 1973.
The authors thank M. Ya. Karpeiskii for his constant interest in the work and for valuable critical observations.
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Kolobushkina, L.I., Kritsyn, A.M. & Florent'ev, V.L. Synthesis of 4-thiouridine derivatives. Chem Heterocycl Compd 9, 917–921 (1973). https://doi.org/10.1007/BF00471583
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DOI: https://doi.org/10.1007/BF00471583