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Chemistry of Heterocyclic Compounds

, Volume 9, Issue 7, pp 917–921 | Cite as

Synthesis of 4-thiouridine derivatives

  • L. I. Kolobushkina
  • A. M. Kritsyn
  • V. L. Florent'ev
Article
  • 47 Downloads

Abstract

The thionation of a protected uridine with the aid of P2S5 has given the corresponding 4-thiouridine derivatives, which have been phosphorylated at the 5′ or the 2′(3′)hydroxyl. On being heated in aqueous pyridine solution with liquid hydrogen sulfide, cytidine phosphates also form 4-thiouridine phosphates. 4-Thiouridine 2′,3′-cyclophosphate has been obtained.

Keywords

Hydrogen Phosphate Sulfide Hydroxyl Organic Chemistry 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Publishing Corporation 1975

Authors and Affiliations

  • L. I. Kolobushkina
    • 1
  • A. M. Kritsyn
    • 1
  • V. L. Florent'ev
    • 1
  1. 1.Institute of Molecular BiologyAcademy of Sciences of the USSRMoscow

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