Abstract
The Mannich reaction in a number of 6-(2-furyl)-substituted imidazo[2,1-b]thiazoles is realized initially in the 5 position of the imidazothiazole system, whereas it is also realized in the 5 position of the furan ring in the presence of excess reagents if the latter position is not substituted. Iodomethylation occurs at the N7 atom of imidazothiazole. The Mannich bases of 6-(5-nitro-2-furyl)imidazo[2,1-b]thiazole are iodomethylated only at the aminomethyl group. The pKa values of the series of compounds were measured.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 9, pp. 1208–1211, September, 1975.
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Saldabol, N.O., Zeligman, L.L. & Ritevskaya, L.A. Mannich bases and methiodides of 6-(2-furyl)imidazo[2,1-b]thiazole and its substituted derivatives. Chem Heterocycl Compd 11, 1051–1054 (1975). https://doi.org/10.1007/BF00471294
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DOI: https://doi.org/10.1007/BF00471294