Abstract
The protonation of 4-methoxy-, 4-amino-, and 4-dimethylamino-6-aminopyrimido[4,5-b][1,4]thiazines and N-(4-methoxy-5-pyrimidinyl)acetamidine was studied by 1H and 13C NMR spectroscopy. It is shown that the addition of a proton in the first three compounds takes place at the N5 atom of the thiazine ring, whereas in the case of N-(4-methoxy-5-pyrimidinyl) acetamidine primary protonation is observed at the nitrogen atom of the amidine group, and the second proton adds to the N1 atom of the pyrimidine ring.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 1, pp. 49–54, January, 1979.
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Dvoryantseva, G.G., Ul'yanova, T.N., Filipenko, T.Y. et al. Structure of the cationic forms of pyrimido [4,5-b][1,4]thiazines — A new type of folic acid antagonist. Chem Heterocycl Compd 15, 41–46 (1979). https://doi.org/10.1007/BF00471196
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DOI: https://doi.org/10.1007/BF00471196