Abstract
Thiazole analogs of isomeric isoflavones were synthesized from α-(2,4-dimethyl-5-thiazolyl)-2-hydroxyacetophenones, and their reaction with hydrazine hydrate and alkylating and acylating agents was studied. The reaction of thiazole derivatives of 7-hydroxychromone with hydrazine hydrate proceeds with opening of the pyrone ring and subsequent cyclization of the intermediate to o-hydroxyphenylpyrazole derivatives. The reaction of hydrazine hydrate with thiazole derivatives of 5-hydroxychromone, which proceeds with retention of the pyrone ring, leads to hydrazones. The structures of the new compounds were confirmed by the PMR spectra.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
Literature cited
V. P. Khilya, I. P. Kupchevskaya, A. I. Salikhova, L. G. Grishko, F. S. Babichev, and L. G. Kirillova, Khim. Geterotsikl. Soedin., No. 9, 1180 (1977).
V. A. Baraboi, Biological Action of Phenolic Compounds of Vegetable Origin [in Russian], Naukova Dumka, Kiev (1976), p. 61.
V. P. Khilya, L. G. Grishko, and D. V. Vikhman, Khim.-Farm. Zh., No. 8, 74 (1976).
M. Yu. Kornilov, V. P. Khilya, and L. G. Grishko, Zh. Org. Khim., 9, 2568 (1973).
W. Baker, J. B. Harborne, and W. D. Ollis, J. Chem. Soc., No. 4, 1303 (1952).
W. Baker, G. G. Clarke, and J. B. Harborne, J. Chem. Soc., No. 3, 998 (1954).
Author information
Authors and Affiliations
Additional information
See [1] for communication 6.
Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 1, pp. 25–28, January, 1979.
Rights and permissions
About this article
Cite this article
Khilya, V.P., Vakulenko, V.F. & Kupchevskaya, I.P. Chemistry of heteroanalogs of isoflavones. Chem Heterocycl Compd 15, 19–22 (1979). https://doi.org/10.1007/BF00471190
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00471190