Skip to main content
Log in

Research on lactams

XXIX. Synthesis and some reactions of 2-oxo-3,3-dihydroxy-4-bromohexahydroazepine

  • Published:
Chemistry of Heterocyclic Compounds Aims and scope

Abstract

2-OxO-3,3-dihydroxy-4-bromohexahydroazepine was obtained by bromination of an enamine of α-oxocaprolactam and subsequent hydrolysis of the resulting bromoimmonium salt and by direct bromination of α-oxocaprolactam. The reaction of the product with thiourea, N-substituted o-aminothiophenols, aminouracils, and acetoacetic ester gave derivatives of thiazolo[4,5-c] azepine, azepino[4,3-b][1,4]benzothiazine, azepino [3,4-b]pyrrolo [2,3-d] pyrimidine, and furo[2,3-c] azepine.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Literature cited

  1. R. G. Glushkov, I. M. Zasosova, and I. M. Ovcharova, Khim. Geterotsikl. Soedin., No. 10, 1398 (1977).

    Google Scholar 

  2. R. G. Glushkov, V. A. Volskova, V. G. Smirnova, and O. Yu. Magidson, Dokl. Akad. Nauk SSSR, 187, 327 (1969).

    Google Scholar 

  3. R. G. Glushkov, V. G. Smirnova, and N. A. Novitskaya, Khim.-Farm. Zh., No. 6, 14 (1972).

    Google Scholar 

  4. V. G. Smirnova and R. G. Glushkov, USSR Inventor's Certificate No. 458552; Byul. Izobr., No. 4, 51 (1975).

  5. R. G. Glushkov and V. G. Granik, Usp. Khim., 38, 1989 (1969).

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Additional information

See [1] for communication XXVIII.

Translated from Khimiya Geterotsiklicheskikh Soedlnenii, No. 3, pp. 374–378, March, 1978.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Glushkov, R.G., Smirnova, V.G., Zasosova, I.M. et al. Research on lactams. Chem Heterocycl Compd 14, 306–310 (1978). https://doi.org/10.1007/BF00470565

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00470565

Keywords

Navigation