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Directive nature of the nitration of the oximes of 2-acetylthiophene and 2-propionylthiophene

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

A method of obtaining pure 2-acetyl- and 2-propionyl-5-nitrothiophenes by nitrating the oximes of the corresponding ketones with the subsequent isolation from the mixtures formed of the pure oximes of the 2-acyl-5-nitrothiophenes and their saponification has been developed. The pure 2-acetyl- and 2-propionyl-4-nitrothiophenes have been isolated by crystallization from the products of the nitration of the corresponding ketones, which form in each case a mixture of the corresponding 2-acyl-4-nitro- and 2-acyl-5-nitrothiophenes containing about 90% of the 4-nitro isomer.

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Authors and Affiliations

  1. N. D. Zelinskii Institute of Organic Chemistry, Academy of Sciences of the USSR, Moscow

    B. P. Fabrichnyi, S. M. Kostrova, G. P. Gromova & Ya. L. Gol'dfarb

Authors
  1. B. P. Fabrichnyi
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  2. S. M. Kostrova
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  3. G. P. Gromova
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  4. Ya. L. Gol'dfarb
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Additional information

Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 11, pp. 1483–1486, November, 1973.

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Fabrichnyi, B.P., Kostrova, S.M., Gromova, G.P. et al. Directive nature of the nitration of the oximes of 2-acetylthiophene and 2-propionylthiophene. Chem Heterocycl Compd 9, 1341–1344 (1973). https://doi.org/10.1007/BF00470337

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  • DOI: https://doi.org/10.1007/BF00470337

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