Abstract
It is shown that 2-alkylpyrimidine methiodides in which the alkyl group is activated by electron-acceptor substituents undergo recyclization to the corresponding 2-methylaminopyridines in an alcohol solution of methylamine. Similar recyclization also takes place without quaternization of the pyrimidine ring when there is a strong electron-acceptor substituent (a nitro group) in the ring.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 10, pp. 1400–1405, October, 1978.
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Kost, A.N., Sagitullin, R.S. & Danagulyan, G.G. Action of nucleophilic agents on the pyrimidine ring. Chem Heterocycl Compd 14, 1139–1144 (1978). https://doi.org/10.1007/BF00469959
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DOI: https://doi.org/10.1007/BF00469959