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The effect of multiple rising doses of Ro 11-2465 (serotonin uptake inhibitor) on serotonin content of human platelets

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Abstract

Ro 11-2465, a cyanide derivative of imipramine with serotonin uptake inhibitory properties, was investigated in six healthy volunteers for its effect on serotonin concentration in blood platelets. The initial dose was 1 mg daily, the maximum dose of 3 mg being reached on day 3 and maintained for 7 days.

A significant decrease in the platelet serotonin concentration was not observed until 3 days after the start of drug administration, after which depletion was rapid. After 5 days of treatment, the reduction was about 80% compared to predrug level. Serotonin restoration after drug withdrawal was very slow, and 5 days after discontinuation, it was still 70% below its baseline level.

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Authors and Affiliations

  1. Biological and Medical Research Institute, St. James's Hospital, Dublin, Ireland

    T. Lenehan, M. Kenny, R. Lambe & A. Darragh

  2. Department of Clinical Research and Development, F. Hoffmann-La Roche, Basle, Switzerland

    L. M. O. Omer

Authors
  1. T. Lenehan
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  2. L. M. O. Omer
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  3. M. Kenny
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  4. R. Lambe
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  5. A. Darragh
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Lenehan, T., Omer, L.M.O., Kenny, M. et al. The effect of multiple rising doses of Ro 11-2465 (serotonin uptake inhibitor) on serotonin content of human platelets. Psychopharmacology 74, 1–3 (1981). https://doi.org/10.1007/BF00431746

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  • DOI: https://doi.org/10.1007/BF00431746

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