Summary
We measured an estrogen-receptor-associated protein (ER-D5), estrogen and progesterone receptors (ER;PgR) in samples obtained from 28 female patients with primary breast carcinoma. A correlation of r=0.79 was found between ER-D5 and ER values and between ER-D5 and PgR values in premenopausal woman. In postmenopausal women a correlation (r=0.75) was found only between ER-D5 and ER and not between ER-D5 and PgR. The measurement of this cytosolic protein may be a complementary tool in the management of breast cancer.
References
Coffer AI, Lewis KM, Brockas AJ, King RJB (1985) Monoclonal antibodies against a component related to soluble estrogen receptor. Cancer Res 45:3685–3693
Green GL, Jensen EV (1982) Monoclonal antibodies as probes for estrogen receptor detection and characterization. J Steroid Biochem 16:353–359
Navarro MA, Villabona C, Pandadero M, Bonnin R (1987) Estrogen receptor by enzymeimmunoassay. Discordant findings with respect to dextran-coated charcoal. J Clin Oncol 5:(4)679
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Navarro, M.A., Guardia, M., Arranz, B. et al. ER-D5 antigen in breast cancer. J Cancer Res Clin Oncol 115, 290–291 (1989). https://doi.org/10.1007/BF00391705
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DOI: https://doi.org/10.1007/BF00391705