, Volume 2, Issue 4, pp 351–365 | Cite as

Heparin-binding growth factors and their receptors

  • Bradley B. Olwin


Heparin-binding growth factors modulate diverse biological activities including cellular proliferation, cellular differentiation, morphogenesis, and angiogenesis. Biochemical characterization for two members of the heparin-binding growth factor family, acidic and basic fibroblast growth factors, is extensive, while characterization of the remaining five members is forthcoming. Cell surface receptors have been identified for acidic and basic fibroblast growth factors, but little is known concerning their sites of action in vivo or the mechanisms involved in transducing the energy of growth factor binding to a biological response. An understanding of the biological basis for the diversity of the heparin binding growth factor family and the in vivo actions of these factors will prove a major challenge to future research efforts.

Key words

fibroblast growth factors growth factor receptors embryogenesis cell proliferation cell differentiation 


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Copyright information

© Kluwer Academic Publishers 1989

Authors and Affiliations

  • Bradley B. Olwin
    • 1
  1. 1.Department of BiochemistryUniversity of Wisconsin-MadisonMadisonUSA

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