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Cytotechnology

, Volume 2, Issue 4, pp 317–332 | Cite as

Transforming growth factor-ßs as modulators of pericellular proteolytic events

  • Jorma Keski-Oja
  • Jouko Lohi
  • Marikki Laiho
Article
  • 15 Downloads

Abstract

Since the discovery of transforming growth factor-ß:s an increasing number of different biological effects have been attributed to this group of proteins. Analysis of the cellular responses to TGFß stimulation at the molecular level has indicated that TGFß acts as an activator of transcription of several genes. This may in part explain the plethora of various functions that have been ascribed to TGFß. In addition to the TGFß family of polypeptides there is an increasing number of related factors, whose major roles appear to be involved in developmental processes. A distinct feature of TGFß is its ability to regulate pericellular proteolysis of cultured cells. As yet this property has not been associated with other members of this group of polypeptides. Depending on the target cell type TGFß may either increase or decrease pericellular proteolytic activity. Proteolytic activation of latent TGFß and its possible inhibition by TGFß-induced protease inhibitors could be a physiological feed-back mechanism in the control of proteolytic activity in the vicinity of cells.

Key words

transforming growth factor-ß (TGFß) TGFα, proteolysis growth factor growth inhibitor invasion metastasis 

Abbreviations

GM-CSF

Granulocyte-Monocyte Colony Stimulating Factor

EGF

Epidermal Growth Factor

IL

Interleukin

MIS

Müllerian Inhibitory Substance

NGF

Nerve Growth Factor

PA

Plasminogen Activator

PAI

Plasminogen Activator Inhibitor

PAI-1

Endothelial-type (type-1) Plasminogen Activator Inhibitor

PAI-2

Placental-type (type-2) Plasminogen Activator Inhibitor

PDGF

Platelet Derived Growth Factor

TGFα

Transforming Growth Factor-α

TGFß

Transforming Growth Factor-ß

t-PA

Tissue-type Plasminogen Activator

u-PA

Urokinase-type Plasminogen Activator

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Copyright information

© Kluwer Academic Publishers 1989

Authors and Affiliations

  • Jorma Keski-Oja
    • 1
  • Jouko Lohi
    • 1
  • Marikki Laiho
    • 2
  1. 1.Department of VirologyUniversity of HelsinkiHelsinkiFinland
  2. 2.Cell Biology and Genetics ProgramMemorial Sloan-Kettering Cancer CenterNew YorkUSA

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