, Volume 2, Issue 4, pp 307–316 | Cite as

Transforming growth factor-β receptors

  • Patricia R. Segarini


Transforming growth factor beta (TGF-β) binds specifically and with high affinity to several different cell surface proteins. Low Mr proteins of 50,000 and 80,000 have been termed type I and type II receptors. Intermediate sized binding components of 115,000–140,000 Mr and a high binding components of approximately 250,000 Mr in subunit size have been termed type III receptors. The high Mr component is a proteoglycan containing the glycosaminoglycan chains of heparan sulfate and chondroitin sulfate and the intermediate sized components are its core proteins. Although almost all cells have TGF-β receptors, binding of TGF-β to the type III binding components is restricted to cells of fibroblastic, osteoblastic and chondroblastic origin. The physiological relevance of each individual binding class is unclear. However, recent data indicate that the type III protein does not transmit signals to inhibit cell proliferation, induce protein synthesis, or promote cytomorphological change and that these activities may be mediated through the type I receptor. The mechanism of signal transduction remains unknown, but it does not appear to be associated with tyrosine phosphorylation or phosphorylation of the 40s ribosomal protein S6.

Key words

binding proteins proteoglycan receptors TGF-ß 



Transforming Growth Factor




Epidermal Growth Factor


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Copyright information

© Kluwer Academic Publishers 1989

Authors and Affiliations

  • Patricia R. Segarini
    • 1
  1. 1.Celtrix LaboratoriesCollagen CorporationPalo AltoUSA

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