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Cytotechnology

, Volume 2, Issue 4, pp 287–305 | Cite as

The insulin-like growth factor II/mannose-6-phosphate receptor

IGF-II/Man-6-P receptor
  • Richard G. MacDonald
Article

Abstract

Recent evidence from molecular cloning, biochemical and immunological experiments has established that the cation-independent mannose-6-phosphate (Man-6-P) receptor and insulin-like growth factor-II (IGF-II) receptor are the same protein. Although the role of the IGF-II/Man-6-P receptor as a transporter of hydrolytic enzymes in the biogenesis of lysosomes is certain, elucidation of the receptor's structure has not yet provided major insights into the function of IGF-II binding. Mutually exclusive binding of IGF-II and naturally occurring phosphomannosyl ligands to distinct but proximal sites on the receptor suggests that the IGF-II/Man-6-P receptor cannot simultaneously fulfill the functional requirements of both IGF-II and lysosomal enzymes. Does the receptor transduce on intracellular signal in order to mediate the biological effects of IGF-II? If so, then the receptor must interact with an effector molecule, perhaps a G protein, in the mechanism of IGF-II action. Further information from ligand binding and especially mutagenesis experiments will be needed to elucidate the potentially multiple functions of the IGF-II/Man-6-P receptor.

Key words

insulin-like growth factor-II mannose-6-phosphate lysosomes signal transduction IGF receptor protein sorting 

Abbreviations

IGF

Insulin-like Growth Factor

Man-6-P

Mannose-6-phosphate

PMP

penta-mannosyl-6-phosphate

SDS-PAGE

Sodium Dodecyl Sulfate-polyacrylamide gel electrophoresis

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Copyright information

© Kluwer Academic Publishers 1989

Authors and Affiliations

  • Richard G. MacDonald
    • 1
  1. 1.Department of BiochemistryUniversity of Nebraska Medical CenterOmahaUSA

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