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Cytotechnology

, Volume 2, Issue 4, pp 269–286 | Cite as

Hematopoietic growth factor receptors

  • Jae-Hung Shieh
  • Malcolm A. S. Moore
Article

Abstract

The formation of the cellular constituents of the blood is regulated by a series of endogenous polypeptides with largely paracrine function. A number of these hematopoietic growth factors (HGF's), which include colony stimulating factors, interleukins, and erythropoietin, have been purified to homogeneity and cloned, which in turn has led to extensive investigations of their biochemical properties and biological effects and functions. The HGF's act on target cells by binding to receptors. The kinetics and, to an even larger extent, dynamics of the factor/receptor associations display several intriguing characteristics, most of which are still poorly understood. Herein, the biochemical characteristics of HGF's receptors as well as the binding properties, post-receptor binding events and receptor modulation resulting from the association of HGF's and their target cells are reviewed.

Key words

hematopoiesis growth factor receptors modulation 

Abbreviations

BMDM

Bone Marrow-Derived Macrophages

CSF

Colony-Stimulating Factor

cAMP

cyclic 3′,5′-adenosine monophosphate

EPO

Erythropoietin

fMLP

formyl-methionylleucyl-phenylalanine

IFN

Interferon

IL

Interleukin

LPS

Lipopolysaccharide

PEM

Peritoneal E Exudate Macrophages

PKC

Protein Kinase C

TNF

Tumor Necrosis Factor

TPA

12-O-tetradecanoylphorbol-13-acetate

PtdIns(4,5)P2

Phosphatidylinositol-4,5 bisphosphate

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Copyright information

© Kluwer Academic Publishers 1989

Authors and Affiliations

  • Jae-Hung Shieh
    • 1
  • Malcolm A. S. Moore
    • 1
  1. 1.The James Ewing Laboratory of Developmental HematopoiesisMemorial Sloan-Kettering Cancer CenterNYUSA

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