Abstract
Two organic compounds, diethylstilboestrol a synthetic oestrogen substitute, and cyproheptadine which acts as an appetite stimulant in some mammals, were added separately at 3 different concentrations to diets fed to plaice (Pleuronectes platessa), and their effect on growth examined. Over a 10 week period, low orally-administered diethylstilboestrol (600 μg/kg moist diet) gave rise to increased weight gain, food consumption and food conversion. Higher dietary concentrations of diethylstilboestrol (up to 2400 μg/kg diet) were without effect on these parameters. Cyproheptadine did not stimulate appetite, weight gain or food conversion at any of the levels tested.
Similar content being viewed by others
Literature Cited
Almquist, H. J. and J. B. Merritt: Effects of diethylstilboestrol on gains and feed conversions of turkeys. Poult. Sci. 31, 748–749 (1952).
Andrews, F. N., M. Stob, T. W. Perry and W. M. Beeson: The oral administration of diethylstilboestrol, dienestrol and hexestrol for fattening calves. J. Anim. Sci. 15, 685–688 (1956).
Anonymous: DES — Another black sheep? Nature, Lond. 238, 67–68 (1972).
Beeson, W. M., F. N. Andrews, T. W. Perry and M. Stob: The effect of orally administered stilboestrol and testosterone on growth and carcass composition of swine. J. Anim. Sci. 14, 475–481 (1955).
Box, G. E. P.: Problems in the analysis of growth and wear curves. Biometrics 6, 362–389 (1950).
Burroughs, W., C. C. Culbertson, E. Cheng, W. H. Hale and P. Homeyer: The influence of oral administration of diethylstilboestrol to beef cattle. J. Anim. Sci. 14, 1015–1024 (1955).
Chakrabarty, A. S., R. V. Pillai, D. K. Anand and B. Singh: Effect of cyproheptadine on the electrical activity of the hypothalamic feeding centres. Brain Res., Osaka 6, 561–569 (1967).
Clegg, M. T. and F. D. Carroll: A comparison of the method of administration of stilboestrol on grwoth and characteristics of beef steers. J. Anim. Sci. 16, 662–670 (1957).
Cowey, C. B., J. A. Pope, J. W. Adron and A. Blair: Studies on the nutrition of marine flatfish. Growth of the plaice Pleuronectes platessa on diets containing proteins derived from plants and other sources. Mar. Biol. 10, 145–153 (1971).
Creger, C. R., R. H. Mitchell, M. L. Jones, R. L. Atkinson, J. H. Quisenberry and J. R. Couch: The effects of oral administration of diethylstilboestrol and dienstrol diacetate on growth rate and efficiency of feed utilisation of Beltsville small white turkey broilers. Poult. Sci. 39, 1041–1045 (1960).
Elston, R. C. and J. E. Grizzle: Estimation of time-response curves and their confidence bands. Biometrics 18, 148–159 (1962).
Ghittino, P.: Riposte delle trote d'allevaments al stilboestrols e metiltiuracile. Riv. ital. Pisicicolt Ittiopatol 5, 9–11 (1970).
Hale, W. H., P. G. Homeyer, C. C. Culbertson and W. Burroughs: Response of lambs fed varied levels of diethylstilboestrol. J. Anim. Sci. 14, 909–918 (1955).
Kochakian, C. D. and J. R. Murlin: The effect of male hormone on the protein and energy metabolism of castrate dogs. J. Nutr. 10, 437–439 (1935).
Leech, F. B. and M. J. R. Healy: The analysis of experiments on growth rate. Biometrics 15, 98–106 (1959).
O'Mary, C. C., A. E. Cullison and J. L. Carmon: Implanted and oral stilboestrol for fattening steers. J. Anim. Sci. 18, 14–20 (1959).
Potthoff, R. F. and S. N. Roy: A generalised analysis of variance model useful especially for growth curve problems. Biometrika 51, 313–326 (1964).
Rao, C. R.: Some problems involving linear hypotheses in multivariate analysis. Biometrika 46, 49–58 (1959).
—: The theory of least squares when the parameters are stochastic and its application to the analysis of growth curves. Biometrika 52, 447–458 (1965).
Sprent, P.: Estimation of mean growth curves for groups of organisms. J. theor. Biol. 17, 159–173 (1967).
Wishart, J.: Growth rate determination in nutrition studies with the bacon pig and their analysis. Biometrika 30, 16–28 (1938).
Author information
Authors and Affiliations
Additional information
Communicated by J. H. S. Blaxter, Oban
With an Appendix on Statistics by J. A. Pope and A. M. Shanks
Rights and permissions
About this article
Cite this article
Cowey, C.B., Pope, J.A., Adron, J.W. et al. Studies on the nutrition of marine flatfish. The effect of oral administration of diethylstilboestrol and cyproheptadine on the growth of Pleuronectes platessa . Marine Biology 19, 1–6 (1973). https://doi.org/10.1007/BF00355413
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00355413