Abstract
The met oncogene is the normal counterpart of a chemically-induced transforming gene. The chromosomal localization of met is 7q21–31. In a patient with myelofibrosis and an interstitial deletion on 7q, we demonstrate that a Taq I polymorphism for the met oncogene is lost in the neoplastic cells, thus indicating that the deletion occuring in the long arm of chromosome 7 involves the met locus.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
Abbreviations
- RFLP:
-
Restriction Fragment Length Polymorphism
References
Cooper CS, Park M, Blair DG, Tainsky MA, Huebner K, Croce CM and Van deWoude GF (1984) Molecular cloning of a new transforming gene from a chemically transformed human cell line. Nature 311: 29–33.
Dean M, Park M, LeBeau MM, Robins TS, Diaz MO, Rowley JD, Blair DG and Van deWoude GF (1985) The human met oncogene is related to the tyrosine kinase oncogene. Nature 318: 385–388.
Fialkow PJ, Martin PJ, Najfeld V, Penfold GK, Jacobsonn RJ and Hansen JA (1981) Evidence for a multistep pathogenesis of chronic myelogenous leukemia. Blood 58: 158–163.
Geraedts JPM, DenOttolander GJ, Ploem JE and Muntighe OG (1980) An identical translocation between chromosome 1 and 7 in three patients with myelofibrosis and myeloid metaplasia. Br. J. Hematol. 44: 569–575.
Kere J, Ruutu T and De LaChapelle (1987) Monosomy 7 in granulocytes and monocytes in myelodysplastic syndrome. N. Engl. J. Med. 316: 499–503.
Mecucci C, Ghione F, Tricot G and Van DenBerghe H (1985) Combined trisomy 1q and monosomy 7q due to translocation 1;7 in myelodysplastic syndromes. Cancer Genet. Cytogenet. 18: 193–197.
Mitelman F (1985) Catalogue of chromosome aberrations in cancer. Progress and Topics in Cytogenetics, vol. 5.
Nitta M, Kato Y, Strife A, Wachter M, Fried J, Perz A, Jhaanwar S, Duigou-Ostendorf M, Chaganti RSKK and Clarkson B (1985) Incidence of involvement of the B and T lymphocyte lineages in chronic myelogenous leukemia. Blood 5: 1053–1061.
Schers JMJC, Hustinx TWJ, Holdrinet RSG, Geraedts JPM, Hagemeijer A and Van derBlij-Philipsen M (1984) Translocation 1;7 in dyshematopolesis: Possibly induced with a non-random geographic distribution. Cancer Genet. Cytogenet. 12: 283–294.
Southern EM (1975) Detection of specific sequences among DNA fragments separated by gel electrophoresis. J. Mol. Biol. 98: 53–517.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Rege-Cambrin, G., Guerrasio, A., Serra, A. et al. 7q-and loss of a polymorphism for the met oncogene in a patient with myelofibrosis. Cytotechnology 1, 37–40 (1987). https://doi.org/10.1007/BF00351120
Issue Date:
DOI: https://doi.org/10.1007/BF00351120