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Analysis and some chemical properties of MX (3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone), the potent drinking water mutagen

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Summary

The solubility of the potent drinking water mutagen 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX) in water (50.8, 44.7, 43.7, and 51.0 mg/ml at pH values 2, 5, 7, and 9, respectively) was only slightly dependent on pH, on the contrary to octanol/water partition (log Pow 1.13, 0.84, −0.44, and −1.02 at pH 2, 5, 7, and 9, respectively). MX was stable in ethyl acetate and acidic water solutions. The recovery of MX during isolation from water or urine samples was about 100% but about 73–82% in the methylation process. The alternative isolation and derivatization methods tested for MX did not give better results.

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Authors and Affiliations

  1. Department of Environmental Hygiene and Toxicology, National Public Health Institute, P.O.Box 95, SF-70701, Kuopio, Finland

    T. Vartiainen & K. Heiskanen

  2. Department of Chemistry, University of Kuopio, P.O.Box 6, SF-70211, Kuopio, Finland

    S. Lötjönen

Authors
  1. T. Vartiainen
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  2. K. Heiskanen
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  3. S. Lötjönen
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Vartiainen, T., Heiskanen, K. & Lötjönen, S. Analysis and some chemical properties of MX (3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone), the potent drinking water mutagen. Fresenius J Anal Chem 340, 230–233 (1991). https://doi.org/10.1007/BF00321774

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  • DOI: https://doi.org/10.1007/BF00321774

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