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Blood findings in lymphogranulomatosis X

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Summary

A quantitative analysis of leukocytes in the periphere blood of 16 patients with lymphogranulomatosis X revealed the following findings:

  1. 1.

    The number of total leukocytes, monocytes, neutrophils, and eosinophils varied considerably and showed no clear common tendency.

  2. 2.

    Blood basophils were found to be clearly increased with a mean value of 0.17±0.18×109/l as compared to 55 normal donors (0.04±0.01×109/l).

  3. 3.

    Lymphocyte counts were within the normal range. Lymphopenia was seen in 2 patients.

  4. 4.

    Lymphocytes with azure granules which encompass T-suppressors were found to exceed normal values by a factor of 15.

  5. 5.

    In 14 cases a variable number of hyperbasophil cells were present.

Lymphogranulomatosis X seems to present with a characteristic blood picture which might be of diagnostic aid.

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References

  1. Bergholz M, Bartsch HH, Krueger GRF, Schauer A, Fischer R (1979) Angioimmunoblastische Lymphadenopathie und persistierende Virusinfekt. Klin Wochenschr 57: 1317

    Google Scholar 

  2. Braunsteiner H, Sailer S, Sandhofer F (1965) The relationship between level of triglycerides in platelets and number of basophils in blood. Metabolism 14: 1071

    Google Scholar 

  3. Braunsteiner H, Thumb N (1958) Quantitative Veränderungen der Blutbasophilen und ihre klinische Bedeutung. Acta Haematol 20: 339

    Google Scholar 

  4. Braunsteiner H, Thumb N (1958) Über quantitative Veränderungen der basophilen Leukocyten und ihre Stoffwechselbedeutung. Wien Z Inn Med 39: 285

    Google Scholar 

  5. Brearly RL, Chapman J, Cullen MH, Horton MA, Stansfeld AG, Waters AH (1979) Haematological features of angioimmunoblastic lymphadenopathy with dysproteinemia. J Clin Pathol 32: 356

    Google Scholar 

  6. Cullen MH, Stansfeld AG, Oliver RTD, Lister T, Malpas JS (1979) Angioimmunoblastic lymphadenopathy: Report of 10 cases and review of the literature. Q J Med, New Series XL VIII, No. 1: 151

  7. Flandrin G (1978) Angioimmunoblastic lymphadenopathy. Clinical biological and follow-up study of 14 cases. In: Mathe G, Seligmann M, Tubiana M (eds) Lymphoid neoplasias I. Recent results in cancer research, Vol. 64. Springer, Berlin Heidelberg New York, p 237

    Google Scholar 

  8. Flandrin G, Daniel MT, El Yafi G, Chelloul N (1972) Sarcomatoses ganglionnaires à différenciation plasmocytaire avec anémie hémolytique auto-immune. Actual Hematol 6: 25

    Google Scholar 

  9. Fossati C (1950) The basophil cells of the blood in tuberculosis. Acta Med Scand 138: 457

    Google Scholar 

  10. Frizzera G, Moran EM, Rappaport H (1974) Angio-immunoblastic lymphadenopathy with dysproteinemia. Lancet I: 1070

    Google Scholar 

  11. Frizzera G, Moran EM, Rappaport H (1975) Angio-immunoblastic lymphadenopathy. Diagnosis and clinical course. Am J Med 59: 803

    Google Scholar 

  12. Grossi CE, Webb SR, Zicca A, Lydyard PM, Moretta L, Mingari MC, Cooper MD (1978) Morphological and histochemical analyses of two human T-cell subpopulations bearing receptors for IgM or IgG. J Exp Med 147: 1405

    Google Scholar 

  13. Horne CH, Fraser RA, Petrie JC (1974) Angioimmunoblastic lymphadenopathy with dysproteinemia. Lancet II: 291

    Google Scholar 

  14. Iseman MD, Schwarz MI, Stanford RE (1976) Interstitial pneumonia in angioimmunoblastic lymphadenopathy with dysproteinemia. A case report with special histopathologic studies. Ann Intern Med 85: 752

    Google Scholar 

  15. Juhlin L (1963) Basophil and eosinophil leukocytes in various internal disorders. Acta Med Scand 174: 249

    Google Scholar 

  16. Kehnscherper M, Blau H (1966) Das postprandiale Verhalten von Blutbasophilen und veresterten Serumfettsäuren im Kindesalter. Klin Wochenschr 44: 847

    Google Scholar 

  17. Kimura I, Moritani Y, Nishizaki Y, Tanizaki Y (1968) Clinical significance of basophil leukocytes in bronchial asthma. Acta Med Okayama 22, 203

    Google Scholar 

  18. Klajman A, Yaretzky A, Schneider M, Holoshitz Y, Schneur A, Griffel B (1981) Angioimmunoblastic lymphadenopathy with paraproteinemia. A T- and B-cell disorder. Cancer 48: 2433

    Google Scholar 

  19. Knecht H, Lennert K (1981a) Vorgeschichte und klinisches Bild der Lymphogranulomatosis X (einschließlich (angio) immunoblastischer Lymphadenopathie). Schweiz Med Wochenschr 111: 1108

    Google Scholar 

  20. Knecht H, Lennert K (1981b) Verlauf, Therapie und maligne Transformation der Lymphogranulomatosis X (einschließlich (angio) immunoblastischer Lymphadenopathie). Schweiz Med Wochenschr 111: 1122

    Google Scholar 

  21. Kosmidis PA, Axelrod AR, Palacas C, Stahl M (1978) Angioimmunoblastic lymphadenopathy: a T-cell deficiency. Cancer 42: 447

    Google Scholar 

  22. Lennert K (1961) Die Plasmazellen und ihre Vorstufen. In: Lymphknoten. Diagnostic in Schnitt und Ausstrich. Cytologie und Lymphadenitis. Handbuch der speziellen pathologischen Anatomie und Histologie. Vol. 1, Part 3A. Springer, Berlin Göttingen Heidelberg, p 86

    Google Scholar 

  23. Lennert K (1973) Pathologisch-histologische Klassifizierung der malignen Lymphome. In: Stacher A (ed) Leukämien und maligne Lymphome. Urban und Schwarzenberg, München Berlin Wien, p 181

    Google Scholar 

  24. Lennert K (1979) Zur Natur und Nomenklatur der angioimmunoblastischen Lymphadenopathie. (Lymphogranulomatosis X bzw. T-Zonen-Lymphom) Dtsch Med Wochenschr 104: 1246

    Google Scholar 

  25. Lennert K, Knecht H, Burkert M (1979) Vorstadien maligner Lymphome. Verh Dtsch Ges Pathol 63: 170

    Google Scholar 

  26. Lennert K, Parwaresch MR (1970) Die Reaktion der basophilen Granulocyten auf eine postprandiale Hyperlipämie. Schweiz Med Wochenschr 100: 1410

    Google Scholar 

  27. Lukes RJ, Tindle BH (1975) Immunoblastic lymphadenopathy. A hyperimmune entity resembling Hodgkin's disease. N Engl J Med 292: 1

    Google Scholar 

  28. Lukes RJ, Tindle BH (1978) Immunoblastic lymphadenopathy: A prelymphomatous state of immunoblastic sarcoma. In: Mathe G, Seligmann M, Tubiana M (eds) Lymphoid neoplasias I. Recent results in cancer research, Vol. 64. Springer, Berlin Heidelberg New York, p 241

    Google Scholar 

  29. Matz LR (1977) Angioimmunoblastic lymphadenopathy with dysproteinemia. Cancer 40: 2152

    Google Scholar 

  30. Moretta L, Webb SR, Grossi CE, Lydyard PM, Cooper MD (1977) Functional analysis of two human T-cell subpopulations: help and suppression of B-cell responses. J Exp Med 146: 184

    Google Scholar 

  31. Nathwani BN, Rappaport H, Moran EM, Pangalis GA, Kim H (1978) Malignant lymphoma arising in angioimmunoblastic lymphadenopathy. Cancer 41: 578

    Google Scholar 

  32. Pangalis GA, Moran EM, Rappaport H (1978) Blood and bone marrow findings in angio-immunoblastic lymphadenopathy. Blood 51: 71

    Google Scholar 

  33. Parwaresch MR (1976) The human blood basophil. Morphology, origin, kinetics, function and pathology. Springer, Berlin Heidelberg New York

    Google Scholar 

  34. Rudders RA, DeLellis R (1977) Immunoblastic lymphadenopathy. A mixed proliferation of T and B lymphocytes. Am J Clin Pathol 68: 518

    Google Scholar 

  35. Sahi J, Stobbe H, Klatt R, Heine KM, Hofer E (1971) Die Azurgranulation der Lymphozyten. Teil I: Literaturübersicht und Festlegung von Normwerten. Folia Haematol (Leipz) 95: 372

    Google Scholar 

  36. Saku T, Tokunaga M, Sato E, Nishioka K, Matsumoto T, Nomura T (1979) Immunoblastic lymphadenopathy. Report of an autopsy case started with rubella infection. J Kyn Hematol Soc 27: 15

    Google Scholar 

  37. Schoengen A, Feyen H, Kubanek B, Heimpel H (1975) Immunoblastische Lymphadenopathie. Blut 31: 190

    Google Scholar 

  38. Schoengen A, Feyen H, Haferkamp O, Heimpel H, Kubanek B (1977) Immunoblastische Lymphadenopathie — maligne Neoplasie oder hyperimmunisatorische Reaktion? Klin Wochenschr 55: 265

    Google Scholar 

  39. Schnaidt U, Vykoupil KF, Thiele J, Georgii A (1980) Angioimmunoblastic lymphadenopathy. Histopathology of bone marrow involvement. Virchows Arch A [Pathol Anat] 389: 369

    Google Scholar 

  40. Shelley WB, Parnes HM (1965) The absolute basophil count. J Am Med Wom Assoc 192: 108

    Google Scholar 

  41. Valdes AJ, Blair OM (1976) Angioimmunoblastic lymphadenopathy with dysproteinemia — Immunohistology and ultrastructural studies. Am J Clin Patho 66: 551

    Google Scholar 

  42. Westerhausen M, Oehlert W (1972) Chronisches pluripotentielles immunproliferatives Syndrom. Dtsch Med Wochenschr 97: 1407

    Google Scholar 

  43. Westerhoff H (1966) Untersuchungen der Blutbasophilen bei verschiedenen Arthropathien unter besonderer Berücksichtigung der Gicht. Dissertation, Münster

    Google Scholar 

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Authors and Affiliations

  1. Pathologisches Institut der Universität Kiel, Hospitalstr. 42, D-2300, Kiel, Federal Republic of Germany

    R. Zankowich, M. R. Parwaresch & K. Lennert

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  1. R. Zankowich
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  2. M. R. Parwaresch
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  3. K. Lennert
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Zankowich, R., Parwaresch, M.R. & Lennert, K. Blood findings in lymphogranulomatosis X. Blut 48, 99–107 (1984). https://doi.org/10.1007/BF00320036

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