Summary
Rapid eye movement (REM) sleep latency (time from sleep onset to the first REM episode) was measured in 39 patients with idiopathic Parkinson's disease. Reduced REM sleep latency (≤65.0 min) was found in a high proportion of patients (69%). Since reduced REM sleep latency may be a trait-like abnormality relatively specific to primary depression, we evaluated this parameter in two groups of parkinsonian patients: depressed (16 patients) and non-depressed (23 patients). Its incidence was significantly higher in depressed patients with Parkinson's disease.
References
American Psychiatric Association (1980) Diagnostic and statistical manual of mental disorders; 3rd edn. Washington, DC, pp 205–224
Apps MCP, Sheaff PC, Ingram DA, Kennard C, Empey DW (1985) Respiration and sleep in Parkinson's disease. J Neurol Neurosurg Psychiatry 48:1240–1245
Bergozzi P, Chiurilla C, Ganuti D, Memuni G, Pinto F (1975) L-dopa plus dopa decarboxylase inhibitor: sleep organization in Parkinson's syndrome before and after treatment. Acta Neurol Psychiatr Belg 75:5–10
Coble PA, Kupfer DJ, Spiker DG, Neil JF, McPortland RJ (1979) EEG sleep in primary depression: a longitudinal placebo study. J Affect Dis 1:131–139
Coble PA, Kupfer DJ, Shaw DH (1981) Distribution of REM latency in depression. Biol Psychiatry 16:453–465
Feinberg M, Gillin JD, Carroll DJ, Gredan JF, Zis AP (1982) EEG studies of sleep in the diagnosis of depression. Biol Psychiatry 17:305–316
Giles DE, Jarrett RB, Roffwarg HP, Rush AJ (1987) Reduced rapid eye movement latency. Neuropsychopharmacology 1:33–39
Gillin JC, Duncan W, Pettegrew KD, Frankel BL, Snyder F (1979) Successful separation of depressed, normal, and insomniac subjects by EEG sleep data. Arch Gen Psychiatry 36:85–90
Gotham AM, Brown RG, Marsden CD (1986) Depression in Parkinson's disease: a quantitative and qualitative analysis. J Neurol Neurosurg Psychiatry 49:381–389
Hamilton M (1960) A rating scale for depression. J Neurol Neurosurg Psychiatry 23:56–62
Hauri P, Chernik D, Hawkins D, Mendels J (1974) Sleep of depressed patients in remission. Arch Gen Psychiatry 31:386–391
Hoehn MM, Yahr MD (1967) Parkinsonism: onset, progression and mortality. Neurology 17:427–442
Hoehn MM, Crowley TJ, Rutledge CO (1976) Dopamine correlates of neurological and psychological status in untreated parkinsonism. J Neurol Neurosurg Psychiatry. 39:941–951
Horn S (1974) Some psychological factors in Parkinsonism. J Neurol Neurosurg Psychiatry 37:27–31
Kales A, Amsel R, Markham C, Scharf M, Tan TL (1971) Sleep in patients with Parkinson's disease and normal subjects prior to and following levodopa administration. Clin Pharmacol Ther 12:397–406
Kendel K, Beck U, Wita C, Hohneck E, Zimmermann K (1972) Der Einfluß von L-Dopa auf den Nachtschlaf bei Patienten mit Parkinson-Syndrom. Arch Psychiatr Nervenkr 216:82–100
Kostić VS, Djuricic BM, Čovičković-Šternić N, Bumbasirevic Lj, Nikolic M, Mrsulja BB (1987) Depression and Parkinson's disease: possible role of serotonergic mechanisms. J Neurol 234:94–96
Kupfer DJ (1976) A psychobiologic marker for primary depressive disease. Biol Psychiatry 11:159–174
Kupfer DJ (1981) Application of EEG sleep in the treatment of depression. In: Mendlewicz J, Praag HM van (eds) Electroneurophysiology and psychopathology. Karger, New York, pp 87–93
Kupfer DJ (1982) EEG sleep as a biological marker in depression. In: Hanin I, Usdin E (eds) Biological markers in psychiatry and neurology. Pergamon Press, New York, pp 387–396
Kupfer DJ, Foster FG (1972) Interval between onset of sleep and rapid eye movement sleep as an indicator of depression. Lancet II:684–686
Mayeux R, Stern Y, Rosen J, Leventhal J (1981) Depression, intellectual impairment, and Parkinson disease. Neurology 31:645–650
Mayeux R, Stern Y, Cote L, Williams JBW (1984) Altered serotonin metabolism in depressed patients with Parkinson's disease. Neurology 34:642–646
Mayeux R, Stern Y, Williams JBW, Cote L, Frantz A, Dyrenfurth I (1986) Clinical and biochemical features of depression in Parkinson's disease. Am J Psychiatry 143:756–759
Mindham RHS (1970) Psychiatric syndromes in parkinsonism. J Neurol Neurosurg Psychiatry 30:188–191
Mindham RHS, Marsden CD, Parkes JD (1976) Psychiatric symptoms during L-dopa therapy for Parkinson's disease and their relationship to physical disability. Psychol Med 6:23–33
Patrick HT, Levy L (1922) Parkinson's disease: a clinical study of 146 cases. Arch Neurol Psychiatry 7:711–720
Rush AJ, Giles DE, Roffwarg HP, Parker CP (1982) Sleep EEG and dexamethasone suppression test findings in outpatients with unipolar major depressive disorder. Biol Psychiatry 17:327–341
Rush AJ, Erman MK, Giles DE, Schlesser MA, Carpenter G, Vasavada N, Roffwarg HP (1986) Polysomnographic findings in recently drug-free and clinically remitted depressed patients. Arch Gen Psychiatry 43:878–884
Thase ME, Kupfer DJ, Ulrich RF (1986) Electroencephalographic sleep in psychotic depression. Arch Gen Psychiatry 43:886–893
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Kostić, V.S., Šušić, V., Čovičković-Šternić, N. et al. Reduced rapid eye movement sleep latency in patients with parkinson's disease. J Neurol 236, 421–423 (1989). https://doi.org/10.1007/BF00314903
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DOI: https://doi.org/10.1007/BF00314903