Skip to main content

Development of the origin of the coronary arteries, a matter of ingrowth or outgrowth?

Summary

Inconsistencies still exist with regard to the exact mode of development of proximal coronary arteries and coronary orifices. In this regard 15 quail embryos were investigated using a monoclonal anti-endothelium antibody, enabling a detailed study of the development of endothelium-lined vasculature. Coronary orifices emerged at 7–9 days of incubation (Zacchei stages 24–26) and were invariably present at 10 days of incubation (Zacchei stage 27).

We never observed more than 2 coronary orifices; these were always single in either of the facing sinuses of the aorta. A coronary orifice was always observed being connected to an already developed proximal coronary artery, which belonged to a peritruncal ring of coronary arterial vasculature. We did not find any coronary orifice without a connection to a proximal coronary artery. Moreover, at 7–9 days of incubation (Zacchei stages 24–26) we observed coronary arteries from the peritruncal ring penetrating the aortic media. In 2 specimen this coronary artery, with a lumen, was in contact with the still intact endothelial lining of the aorta.

We conclude that coronary arteries do not grow out of the aorta, but grow into the aorta from the peritruncal ring of coronary arterial vasculature. This throws new light on normal and abnormal development of proximal coronary arteries and coronary orifices.

This is a preview of subscription content, access via your institution.

References

  1. Abrikosoff A (1911) Aneurysma des linken Ventrikels mit abnormer Abgangstelle der linken Koronararterie von der Pulmonalis bei einem fünfmonatlichen Kinde. Virchows Arch Pathol Anat 2203:413–420

    Google Scholar 

  2. Aikawa E, Kawano J (1982) Formation of coronary arteries sprouting from the primitive aortic sinus wall of the chick embryo. Experientia 38:816–818

    Google Scholar 

  3. Bartelings MM, Gittenberger-de Groot (1988) The arterial orifice level in the early human embryo. Anat Embryol 177:537–542

    Google Scholar 

  4. Bland EF, White PD, Garland J (1933) Congenital anomalies of the coronary arteries: report of an unusual case associated with cardiac hypertrophy. Am Heart J 8:787–801

    Google Scholar 

  5. Bogers AJJC, Gittenberger-de Groot AC, Dubbeldam JA, Huysman HA (1988a) The inadequacy of existing theories on development of the proximal coronary arteries and their connections with the arterial trunks. Int J Cardiol 20:117–123

    Google Scholar 

  6. Bogers AJJC, Quaegebeur JM, Huysmans HA (1988b) The need for follow-up after surgical correction of anomalous left coronary artery arising from the pulmonary artery. J Cardiovasc Surg 29:339–342

    Google Scholar 

  7. Corone P, Corone A, Dor X, Binet JP (1984) Les artères coronaires et leurs variations, une explication embryologique. C R Acad Sc Paris 299 [III]:451–458

    Google Scholar 

  8. Dbaly J, Ostadal B, Rychter Z (1968) Development of the coronary arteries in rat embryos. Acta Anat 71:209–222

    Google Scholar 

  9. Gittenberger-de Groot AC, Sauer U, Oppenheimer-Dekker A, Quaegebeur JM (1983) Coronary arterial anatomy in transposition of the great arteries: a morphological study. Pediatr Cardiol 4 [Suppl 1]:15–24

    Google Scholar 

  10. Gittenberger-de Groot AC, Bogers AJJC, Bartelings MM (1987) Aspects of normal and abnormal development of the main coronary arteries. In: Spaan JAE, Bruschke AVG, Gittenberger-de Groot AC (eds) Coronary circulation. Dordrecht, Nyhoff, pp 32–42

    Google Scholar 

  11. Hackensellner A (1956) Akzessorische Kranzgefäßanlagen der Arteria pulmonalis unter 63 menschlichen Embryonen-Serien mit einer größten Länge von 12 bis 36 mm. Z Mikrosk Anat Forsch 62:153–164

    Google Scholar 

  12. Heintzberger CFM (1983) Development of myocardial vascularization in the rat. Acta Morphol Neerl Scand 21:267–284

    Google Scholar 

  13. Hirakow R (1983) Development of the cardiac blood vessels in staged human embryos. Acta Anat 15:220–230

    Google Scholar 

  14. Hutchins GM, Kessler-Hanna A, Moore GW (1988) Development of the coronary arteries in the embryonic human heart. Circulation 77:1250–1257

    Google Scholar 

  15. Labastie MC, Poole TJ, Péault BM, Le Douarin NM (1986) MB1, a quail leukocyte-endothelium antigen: partial characterization of the cell surface and secreted forms in cultured endethelial cells. Proc Natl Acad Sci USA 83:9016–9020

    Google Scholar 

  16. Ogden JA (1988) The origin of the coronary arteries [Abstr]. Circulation 38[Suppl 4]:150

    Google Scholar 

  17. Péault BM (1987) MB1, a quail leukocyte/vascular endothelium antigen: characterization of the lymphocyte-surface form and identification of its secreted counterpart as alpha-2-macroglobulin. Cell Differ 21:175–187

    Google Scholar 

  18. Péault BM, Thiery JP, Le Douarin NM (1983) Surface marker for hemopoietic and endothelial cell lineages in quail that is defined by a monoclonal antibody. Proc Natl Acad Sci USA 80:2976–2980

    Google Scholar 

  19. Péault BM, Coltey M, Le Douarin NM (1988) Ontogenic emergence of a quail leukocyte/endothelium cell surface antigen. Cell Differ 23:165–174

    Google Scholar 

  20. Quaegebeur JM, Rohmer J, Ottenkamp J, Buis T, Kirklin JW, Blackstone EH, Brom AG (1986) The arterial switch operation, an eight-year experience. J Thor Cardiovasc Surg 92:361–384

    Google Scholar 

  21. Zacchei AM (1961) Sviluppo embrionale della quaglia giapponese (Coturnix coturnix japonica). Arch Ital Anat Embriol 66:36–63

    Google Scholar 

  22. Zuber M, Wortmann J (1984) Untersuchung zur Entwicklung des Koronargefäßsystems bei der Maus. Verh Anat Ges 78:269–270

    Google Scholar 

Download references

Author information

Affiliations

Authors

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Bogers, A.J.J.C., Gittenberger-de Groot, A.C., Poelmann, R.E. et al. Development of the origin of the coronary arteries, a matter of ingrowth or outgrowth?. Anat Embryol 180, 437–441 (1989). https://doi.org/10.1007/BF00305118

Download citation

Key words

  • Coronary artery development
  • Coronary orifice development
  • Peritruncal ring