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Probable pericentric inversion in chromosome No. 1 in a female child (46,XX,inv(Ip+q-))

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Summary

A newborn female child with multiple developmental anomalies is described. The karyotype analysis performed on the chromosome preparations of the peripheral blood culture disclosed one of the homologues of the 1st chromosome pair to be morphologically changed. The results of the length measurement and the following statistical analysis allow to suppose the existence of a pericentric inversion. The parents' karyotypes are normal.

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Authors and Affiliations

  1. Laboratory of Karyology, Institute of Molecular Biology of Academy of Sciences of UdSSR, Vavilov str.32, B-312, Moscow

    Aavo-Valdur Neeme Mikelsaar & Eugene Vitaljevitch Ananjev

  2. Laboratory of General Pathophysiology, Institute of Psychiatry of Academy of Medical Sciences of UdSSR, Zagorodnoe chosse 2, B-152, Moscow

    Viktor Mironovitch Gindilis

Authors
  1. Aavo-Valdur Neeme Mikelsaar
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  2. Eugene Vitaljevitch Ananjev
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  3. Viktor Mironovitch Gindilis
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Mikelsaar, AV.N., Ananjev, E.V. & Gindilis, V.M. Probable pericentric inversion in chromosome No. 1 in a female child (46,XX,inv(Ip+q-)). Hum Genet 9, 316–324 (1970). https://doi.org/10.1007/BF00286996

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  • DOI: https://doi.org/10.1007/BF00286996

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