Summary
Diabetes prone NOD female mice were fed diets containing different proteins from just before weaning. Only mice receiving meat meal or casein as the protein source developed diabetes at the rate expected from this colony. Lactalbumin and gluten did not precipitate diabetes except in a small number. Casein hydrolysate in lieu of protein protects against overt diabetes, but only if introduced early. The animals which did not show overt diabetes nevertheless had intermittent trace glycosuria and the majority showed mild degrees of peninsular lymphocytic infiltration.
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References
Yamada K, Nonaka K, Hanafusa T, Miyazaki A, Toyoshima H, Tarui S (1982) Preventive and therapeutic effects of large-dose nicotinamide injections on diabetes associated with insulitis. An observation in non-obese diabetic (NOD) mice. Diabetes 31: 749–753
Elliott RB, Martin JM (1984) Dietary protein: a trigger of insulin-dependent diabetes in the BB rat? Diabetologia 26: 297–299
Makino S, Kunimoto K, Muraoka Y, Mizushima Y, Katagiri K, Tochino Y (1980) Breeding of a non-obese, diabetic strain of mice. Exp Anim 29: 1–13
Borch-Johnsen K, Mandrup-Poulsen T, Zachau-Christiansen B, Joner G, Christy M, Kastrup K, Nerup J (1984) Relation between breast-feeding and incidence rates of insulin-dependent diabetes mellitus. Lancet II: 1083–1086
Scott FW, Mongeau R, Kardish M, Hatina G, Trick KD, Wojcinski Z (1985) Diet can prevent diabetes in the BB rat. Diabetes 34: 1059–1062