Summary
Radioimmunoassays for 2 synthetic progestins (Ethinyl-norgestrienone, R 2323 and medroxyprogesterone acetate, MPA) are demonstrated. 10 patients aged 31 to 72 years were treated with ethinyl-norgestrienone with different schedules and 3 men suffering from benign prostatic hypertrophy were treated with medroxyprogesterone acetate. Plasma levels of testosterone, LH, FSH were monitored before, during and after treatment.
Similar content being viewed by others
References
Bartke, A., Steele, R. E., Musto, N., Caldwell, B. V.: Fluctuations in plasma testosterone levels in adult male rats and mice. Endocrinology 92, 1223 (1973)
Cornette, J. C. et al.: Measurement of medroxyprogesterone acetate (Provera) by radioimmunoassay. Journal of Clinical Endocrinology and Metabolism 33, 459 (1971)
Coyotupa, J., Parlow, A. F., Abraham, G. E.: Simultaneous radioimmunoassay of plasma testosterone and dihydrotestosterone. Anal Lett 5, 329 (1972)
Crosignani, P. G., Nakamura, R. M. Hovland, D. N., Mishell, D. R., Jr.: A method of solid phase radioimmunoassay utilizing polypropylene discs. Journal of Clinical Endocrinology and Metabolism 30, 153 (1970)
Edquist, L. E., Johansson, E. D.: Radioimmunoassay of oestrone and oestradiol in human and bovine peripheral plasma. Acta endocrinologica 71, 716 (1972)
Frick, J.: Control of spermatogenesis in men by combined administration of progestin and androgen. Contraception 8, 103 (1973)
Greenwood, F. C., Hunter, W. M., Glover, J. S.: The preparation of 131I-labelled human growth hormone of high specific radioactivity. Biochemical Journal 89, 114 (1963)
Johansson, E. D. B., Nygren, K. G.: Depression of plasma testosterone levels in men with norethindrone. Contraception 8, 219 (1973)
Kaiser, D. G., Carlson, R. G., Kirton, K. T.: GLC determination of medroxyprogesterone acetate in plasma. Journal of Pharmaceutical Sciences 63, 420 (1974)
Kirton, K. T., Cornette, J. C.: Return of ovulatory cyclicity following an intramuscular injection of medroxy-progesterone acetate (Provera). Contraception 10, 39 (1974)
Viinikka, L., Johansson, E. D. B., Jänne, O., Victor, A.: The release of a synthetic progestin, R-2323, from polysilastic vaginal rings. (Submitted for Publication)
Zanartu, J., Pupkin, M., Rosenberg, D.: Long-term effect of medroxy-progesterone acetate in human ovarian morphology and sperm transport. Fertility and Sterility 21, 525 (1970)
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Frick, J., Bartsch, G. & Jakse, G. Radioimmunoassays of Ethinyl-norgestrienone (R-2323) and medroxyprogesterone acetate (MPA) and their clinical applicability. Urol. Res. 5, 55–59 (1977). https://doi.org/10.1007/BF00256842
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00256842