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VP16-213 and cyclophosphamide in non oat cell bronchogenic carcinoma

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  • Lung Cancer, VP16-213 Cyclophosphamide Short Report
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Summary

Thirty-two patients with by non oat cell bronchogenic carcinoma were admitted to a protocol including Cyclophosphamide (CTX) 1,000 mg/m2 i.v. day 1, VP16-213 200 mg/m2 p.o. day 1–3, every 3 weeks.

Partial remissions were seen in 2 of 27 evaluable patients; 16 of 27 showed no change. Mean survival was 36.4 weeks, median survival was 38 weeks.

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References

  1. Bitran JD, Desser RK, DeMeester TR, Colman M, Evans R, Billings A, Griem M, Rubenstein L, Shapiro C, Golomb HM (1976) Cyclophosphamide, adriamycin, methotrexate, and procarbazine (CAMP)-Effective four-drug combination chemotherapy for metastatic-on-óat cell bronchogenic carcinoma. Cancer Treat Rep 60:1225

    Google Scholar 

  2. Cohen MH, Ihde DC, Bunn PA Jr, Fossieck BE, Matthews MJ, Shackney SE, Johnston-Early A, Makuch R, Minna JD (1979) Cyclic alternating combination chemotherapy for small cell bronchogenic carcinoma. Cancer Treat Rep 63:163

    Google Scholar 

  3. Eagan RT, Ingle JN, Creagan ET, Frytak S, Kvols LK, Rubin J, McMahon RT (1978) VP16-213 chemotherapy for advanced squamous cell carcinoma and adenocarcinoma of the lung. Cancer Treat Rep 62:843

    Google Scholar 

  4. EOTC (European Organization for Research on the Treatment of Cancer, Clinical Screening Group) (1973) Epipodophyllotoxin VP16-213 in treatment of acute leukaemias, haematosarcomas, and solid tumours. Br Med J 3:199

    Google Scholar 

  5. Issel BF (1978) Clinical brochure etoposide (VP16-213). Dept. Clinical Cancer Research, Bristol Lab., Syracuse, New York

    Google Scholar 

  6. Livingston RB, Fee WH, Einhorn LH, Burgess MA, Freireich EJ, Gottlieb JA, Farber MO (1976) BACON (bleomycin, adriamycin, CCNU, oncovin, and nitrogen mustard) in squamous lung cancer. Experience in fifty patients. Cancer 37:1237

    Google Scholar 

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Morasca, L., Marsoni, S., Pisoni, M.B. et al. VP16-213 and cyclophosphamide in non oat cell bronchogenic carcinoma. Cancer Chemother. Pharmacol. 7, 209–210 (1982). https://doi.org/10.1007/BF00254551

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  • DOI: https://doi.org/10.1007/BF00254551

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