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The effects of low doses of caffeine on human performance and mood

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Abstract

Caffeine is thought to have stimulant-like behavioral effects on mood and performance. However few behavioral studies have examined this substance's acute effects when administered in a range of doses that include the low doses typically found in foods and over-the-counter drugs. We therefore gave single doses of caffeine (32, 64, 128 and 256 mg) to 20 healthy male subjects and assessed various aspects of performance and self-reported mood states, as well as plasma caffeine concentration. As little as 32 mg (which elevated plasma caffeine concentration to less than 1 μg/ml), typical of the dose found in a single serving of a cola beverage, and less than that found in a single cup of coffee or a single dose of over-the-counter drugs, significantly improved auditory vigilance and visual reaction time. All other caffeine doses administered also significantly improved performance on these tests. No adverse behavioral effects, such as increased anxiety or impaired motor performance, were noted even at the highest dose administered.

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References

  • Arnaud MJ (1984) Products of metabolism of caffeine. In: Dews P (ed) Caffeine. Springer, Berlin Heidelberg New York Tokyo, pp 3–38

    Google Scholar 

  • Buchsbaum MS, Sostek AJ (1980) An adaptive-rate continuous performance test: vigilance characteristics and reliability for 400 male students. Percept Mot Skills 51:707–713

    Google Scholar 

  • Childs JM (1978) Caffeine consumption and target scanning performance. Hum Factors 20:91–96

    Google Scholar 

  • Clubley M, Bye CE, Henson TA, Peck AW, Riddington CJ (1979) Effects of caffeine and cyclizine alone and in combination on human performance, subjective effects and EEG activity. Br J Clinical Pharmacol 7:157–163

    Google Scholar 

  • Cole JO, Pope HG, LaBrie R, Ionescu-Pioggia M (1978) Assessing the effects of stimulants in casual users. Clin Pharmacol Ther 24:243–252

    Google Scholar 

  • Corkin S, Growdon JH, Sullivan EV (1981) Dissociation of sensorimotor function in Alzheimer's disease. Am Aging Assoc Abst 11:20

    Google Scholar 

  • Dews PB (1982) Caffeine. Ann Rev Nutr 2:323–341

    Google Scholar 

  • Dews PB (1984) Behavioral effects of caffeine. History and use. In: Dews PD (ed) Caffeine. Springer, Berlin Heidelberg New York Tokyo, pp 86–103

    Google Scholar 

  • Dews P, Grice HC, Neims A, Wilson J, Wurtman R (1984) Report of fourth international caffeine workshop, Athens, 1982. Fd Chem Toxicol 22(2):163–169

    Google Scholar 

  • Dobmeyer DJ, Stine RA, Leier CV, Greenberg R, Schaal SF (1983) The arrhythmogenic effects of caffeine in human beings. N Engl J Med 308:814–816

    Google Scholar 

  • File SA, Bond AJ, Lister RG (1982) Interaction between effects of caffeine and lorazepam in performance tests and self-ratings. J Clin Psychopharmacol 2:102–106

    Google Scholar 

  • Franks HM, Hagendorn H, Hensley VR, Stramer GA (1975) The effect of caffeine on human performance, alone and in combination with ethanol. Psychopharmacologia 45:177–181

    Google Scholar 

  • Gelenberg AJ, Wojcik JD, Gibson CJ, Wurtman RJ (1983) Tyrosine for depression. J Psychiatr Res 17:175

    Google Scholar 

  • Goldstein A, Kaizer S, Warren R (1965) Psychotropic effects of caffeine in man, II. Alertness, psychomotor coordination, and mood. J Pharmacol Exp Ther 150:146–151

    Google Scholar 

  • Harris W (1977) Fatigue, circadian rhythms and truck accidents. In: Mackie RR (ed) Vigilance: theory, operational performance, and physiological correlates. Plenum, New York, pp 133–146

    Google Scholar 

  • Hartmann E (1983) Effects of l-tryptophan on sleepiness and on sleep. J Psychiatr Res 17(2):107–113

    Google Scholar 

  • Hoddes E, Dement W, Zarcone V (1972) The history and use of the Stanford Sleepiness Scale. Psychophysiol 9:150

    Google Scholar 

  • Jick H, Miettinen OS, Neff RK, Shapiro S, Heinonen OP, Slone D (1973) Coffee and myocardial infarction. N Engl J Med 289:63–67

    Google Scholar 

  • Leathwood P, Pollet P (1983) Diet-induced mood changes in normal populations. J Psychiatr Res 17:147

    Google Scholar 

  • Lieberman HR, Corkin S, Spring BJ, Growdon JH, Wurtman RJ (1983) Mood, performance, and pain sensitivity: changes induced by food constituents. J Psychiatr Res 17(2):135–145

    Google Scholar 

  • Lieberman HR, Spring BJ, Garfield GS (1986) The behavioral effects of food constituents: strategies used in studies of amino acids, protein, carbohydrate and caffeine. Nutr Rev [Suppl] 44:61–70

    Google Scholar 

  • Loke WH, Meliska CJ (1984) Effects of caffeine use and ingestion on a protracted visual vigilance task. Psychopharmacology 84:54–57

    Google Scholar 

  • MacMahon B, Yen S, Trichopoulos D, Warren K, Nardi G (1981) Coffee and cancer of the pancreas. N Engl J Med 304:630–633

    Google Scholar 

  • Matthews CG, Haaland KY (1979) The effect of symptom duration on cognitive and motor performance in Parkinsonism. Neurology 29:951–956

    Google Scholar 

  • McNair PM, Lorr M, Droppleman LF (1971) Profile of mood states manual. Educational and Industrial Testing Service, San Diego

    Google Scholar 

  • Regina EG, Smith GM, Keiper CG, McKelvey RK (1974) Effects of caffeine on alertness in simulated automobile driving. J Appl Psychol 59:483–489

    Google Scholar 

  • Roberts HR, Barone JJ (1983) Biological effects of caffeine. History and use. Food Technol 37a:32–39

    Google Scholar 

  • Robertson D, Frolich JC, Carr RK, Watson JT, Hollifield JW, Shand DG, Oates JA (1978) Effects of caffeine on plasma renin activity, catecholamines and blood pressure. N Engl J Med 298:181–186

    Google Scholar 

  • Sawyer DA, Julia HL, Turin AC (1982) Caffeine and human behavior: arousal, anxiety, and performance effects. J Behav Med 5(4):415–439

    Google Scholar 

  • Spindel ER, Arnold M, Cusack B, Wurtman RJ (1980) Effects of caffeine on anterior pituitary and thyroid function in the rat. J Pharmacol Exp Ther 214:58–62

    Google Scholar 

  • Spindel ER, Wurtman RJ, McCall A, Carr DB, Conlay L, Griffith L, Arnold MA (1984) Neuroendocrine effects of caffeine in normal subjects. Clin Pharmacol Ther 36:402–407

    Google Scholar 

  • Spring B, Maller O, Wurtman JJ, Digman L, Cozolino L (1983) Effects of protein and carbohydrate meals on mood and performance: interactions with sex and age. J Psychiatr Res 17(2):155–167

    Google Scholar 

  • Svensson E, Persson L, Sjøberg L (1980) Mood effects of diazepam and caffeine. Psychopharmacology 67:73–80

    Google Scholar 

  • Wilkinson RT (1970) Methods for research on sleep deprivation and sleep function. In: Hartmann E (ed) Sleep and dreaming. Little Brown, Boston, pp 369–381

    Google Scholar 

  • Wilkinson RT, Houghton D (1975) Portable four-choice reaction time test with magnetic tape memory. Behav Res Meth Inst 7:441–444

    Google Scholar 

  • Winer BJ (1971) Statistical principals in experimental design 2nd. Ed. McGraw-Hill, New York

    Google Scholar 

Download references

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Lieberman, H.R., Wurtman, R.J., Emde, G.G. et al. The effects of low doses of caffeine on human performance and mood. Psychopharmacology 92, 308–312 (1987). https://doi.org/10.1007/BF00210835

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  • DOI: https://doi.org/10.1007/BF00210835

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