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Investigational New Drugs

, Volume 1, Issue 3, pp 249–252 | Cite as

The treatment of acute leukemia with continuous infusion L-Alanosine

  • James K. Weick
  • Bill L. Tranum
  • Francis S. Morrison
Clinical

Summary

L-Alanosine, an antitumor antibiotic was administered by members of the Southwest Oncology Group (SWOG) to 22 patients with resistant acute non-lymphocytic leukemia. The drug was administered by continuous infusion for five days at a starting dose of 125 mg/m2/day. Mucositis was dose-limiting in 15 patients and no marrow aplasia was attained. As administered, L-Alanosine is not an effective single agent in acute leukemia.

Key words

acute leukemia chemotherapy L-Alanosine Phase II 

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Copyright information

© Martinus Nijhoff Publishers 1983

Authors and Affiliations

  • James K. Weick
    • 1
  • Bill L. Tranum
    • 2
  • Francis S. Morrison
    • 3
  1. 1.Cleveland Clinic FoundationClevelandUSA
  2. 2.University of Arkansas for Medical SciencesLittle RockUSA
  3. 3.University of Mississippi Medical CenterJacksonUSA

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