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Investigational New Drugs

, Volume 1, Issue 3, pp 235–237 | Cite as

Methyl-glyoxal bis guanyl hydrazone (methyl-GAG, MGBG) in lymphoma and Hodgkin's disease

A Phase II trial of the Southwest Oncology Group
  • William A. T. KnightIII
  • Carol Fabian
  • John J. Costanzi
  • Stephen E. Jones
  • Charles A. ColtmanJr.
Clinical

Summary

The Southwest Oncology Group has evaluated methyl-GAG on a weekly schedule among patients with lymphoma and Hodgkin's disease. Among 56 fully and partially evaluable patients responses were seen in 3 of 10 patients with Hodgkin's disease and 11 of 46 patients with lymphoma. Toxicity was acceptable. Methyl-GAG has significant antitumor activity among this group of heavily pretreated patients. Additional trials of methyl-GAG in combination with other agents are underway.

Key words

methyl-GAG MGBG methyl-GAG in lymphoma 

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References

  1. 1.
    Knight WA III, Livingston RB, Fabian C, Costanzi J: Phase I–II trial of methyl-GAG: A Southwest Oncology Group pilot study. Cancer Treat Rep 63:1933–1937, 1979Google Scholar
  2. 2.
    Warrell RP, Burcheval JH: Methyl glyoxal bis guanyl hydrazone (methyl-GAG): Current status and future prospects. J Clin Oncol 1:52–65, 1983Google Scholar
  3. 3.
    Warrell RP, Burton JL, Kempin SJ, Lacker MJ, Straus DJ, Young CW: Effectiveness of methyl-GAG in patients with advanced malignant lymphoma. Blood 57:1011–1014, 1981Google Scholar
  4. 4.
    Myers JW, Knight WA III, Livingston RB, Fabian C, Costanzi J: Phase I–II, trial of methyl-GAG in advanced colon cancer. A Southwest Oncology Group pilot study. Cancer Clin Trials 4:227–280, 1981Google Scholar
  5. 5.
    Knight WA III, Loesch DM, Leichman L, Fabian C, O'Bryan R: Methyl-GAG in advanced colon cancer. A phase II trial of the Southwest Oncology Group. Cancer Treat Rep 66: 2099–2100, 1982Google Scholar

Copyright information

© Martinus Nijhoff Publishers 1983

Authors and Affiliations

  • William A. T. KnightIII
    • 1
  • Carol Fabian
    • 2
  • John J. Costanzi
    • 3
  • Stephen E. Jones
    • 4
  • Charles A. ColtmanJr.
    • 1
  1. 1.University of Texas Health Science CenterSan AntonioUSA
  2. 2.University of Kansas Medical CenterKansas CityUSA
  3. 3.University of Texas Medical Branch at GalvestonGalvestonUSA
  4. 4.University of ArizonaTucsonUSA

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