Abstract
The effect of theophylline on periodic breathing was measured by transcutaneous oxygen monitoring in 7 patients suffering from chronic congestive heart failure.
Theophylline significantly decreased the frequency of Cheyne — Stokes breathing. Transcutaneous oxygen monitoring proved to be a useful method to follow changes in the breathing pattern.
The suggested mechanism of action of theophylline in reducing the incidence of periodic breathing is blockade of adenosine receptors.
This is a preview of subscription content, log in via an institution to check access.
References
Watt AH, Routledge PA (1985) Adenosine stimulates respiration in man. Br J Clin Pharmacol 20: 503–506
Smits P, Sxhouten J, Thien Th (1987) Respiratory stimulant effects of adenosine in man after caffeine and euprofylline. Br J Clin Pharmacol 24: 816–819
Tomcsányi J, Karlócai K, Juhász J, Naszlady A (1991) Nocturnal periodic breathing in congestive left ventricular dysfunction (abstract). Eur Heart J 12: 330
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Tomcsányi, J., Karlócai, K. Effect of theophylline on periodic breathing in congestive heart failure measured by transcutaneous oxygen monitoring. Eur J Clin Pharmacol 46, 173–174 (1994). https://doi.org/10.1007/BF00199884
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00199884