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Tolerance of full dose menogaril (NSC 269148) in patients with abnormal hepatic and renal function

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Abbreviations

AUC:

Area Under the Plasma Concentration-time Curve

i.v.:

Intravenous, intravenously

Ccr:

Creatinine Clearance

PMN:

Polymorphonuclear Leukocyte, Neutrophil

WBC:

White Blood Cell Count

LFT:

Liver Function Test

PLT:

Platelet Count

HCT:

Hematocrit

TRANSAM:

Serum Hepatic Transaminases

TOT.BILI:

Total Serum Bilirubin

ALK P:

Total Serum Alkaline Phosphatase

BUN:

Serum Urea Nitrogen

Cr:

Serum Creatinine

LDH:

Serum Lactate Dehydrogenase

KPS:

Karnofsky Performance Status

NCI:

National Cancer Institute

References

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  5. Egorin MJ, Conley BA, Forrest A, Zuhowski EG, Sinibaldi V, Van Echo DA: Phase I study and pharmacokinetics of menogaril (NSC 269148) in patients with hepatic dysfunction. Cancer Res 47:6104–6110, 1987

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Authors and Affiliations

  1. Division of Development Therapeutics and Medical Oncology, University of Maryland Cancer Center, USA

    Barbara A. Conley

  2. Division of Development Therapeutics and Medical Oncology, University of Maryland Cancer Center, USA

    Merrill J. Egorin

  3. Division of Medical Oncology, University of Maryland Cancer Center, USA

    Victoria Sinibaldi & David A. Van Echo

  4. Division of Medical Oncology, Department of Medicine, University of Maryland School of Medicine, 21201, Baltimore, Maryland, USA

    David A. Van Echo

  5. Division of Medical Oncology, Department of Medicine, University of Maryland School of Medicine, 21201, Baltimore, Maryland, USA

    Merrill J. Egorin

  6. Division of Medical Oncology, Department of Medicine, University of Maryland School of Medicine, 21201, Baltimore, Maryland, USA

    Barbara A. Conley

Authors
  1. Barbara A. Conley
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  2. Merrill J. Egorin
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  3. Victoria Sinibaldi
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  4. David A. Van Echo
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Conley, B.A., Egorin, M.J., Sinibaldi, V. et al. Tolerance of full dose menogaril (NSC 269148) in patients with abnormal hepatic and renal function. Invest New Drugs 8, 365–367 (1990). https://doi.org/10.1007/BF00198592

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  • DOI: https://doi.org/10.1007/BF00198592

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