Summary
The NCI Canada Clinical Trials Group conducted a phase II study of menogaril given intravenously every 4 weeks in low-grade non-Hodgkin's lymphoma. Fifteen of 26 eligible patients had had no prior therapy. Partial responses were seen in 9 patients (35%). Toxicity was moderate including myelosuppression, nausea, phlebitis, alopecia, and lethargy. This drug has only modest activity in this potentially responsive group of patients.
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Skillings, J., Cripps, C., Eisenhauer, E. et al. A phase II study of menogaril in low-grade non-Hodgkin's lymphoma. Invest New Drugs 9, 79–82 (1991). https://doi.org/10.1007/BF00194551
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DOI: https://doi.org/10.1007/BF00194551