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Hypoprothrombinemia from coadministration of sulofenur (LY 186641) and warfarin: Report of three cases

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References

  1. Kuhn J, Craig J, Havlin K, Brown T, Beougher K, von Hoff D, Satterlee W, Hamilton M, Grindley G: Phase I clinical and pharmacokinetic evaluation of oral LY 186641 administered on a single dose Q21d schedule. Proc Am Soc Clin Oncol 7:60, 1988 (Abstr)

    Google Scholar 

  2. Taylor CW, Alberts DS, Ketcham MA, Satterlee WG, Holdsworth MT, Plezia PM, Peng YM, McCloskey TM, Roe DJ, Hamilton M, Salmon SE: Clinical pharmacology of a novel diarylsulfonylurea anticancer agent. J Clin Oncol 7:1733–1740, 1989

    Google Scholar 

  3. Aggeler PM, O'Reilly RA, Leong L, Kowitz PE: Potentiation of anticoagulant effect of warfarin by phenylbutazone. N Engl J Med 276:465–501, 1967

    Google Scholar 

  4. Eisen MJ: Combined effect of sodium warfarin and phenylbutazone. JAMA 189:64–65, 1964

    Google Scholar 

  5. Solomon HM, Schrogie JJ: The effect of various drugs on the binding of warfarin-C14 to human albumin. Biochem Pharmacol 16:1219–1226, 1967

    Google Scholar 

  6. Solomon HM, Schrogie JJ, Williams D: The displacement of phenylbutazone-C14 and warfarin-C14 from human albumin by various drugs and fatty acids. Biochem Pharmacol 17:143–151, 1968

    Google Scholar 

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Authors and Affiliations

  1. Department of Medical Oncology, The University of Texas M.D. Anderson Cancer Center, 77030, Houston, Texas, USA

    Frank V. Fossella & Scott M. Lippman

  2. Eli Lilly and Co., Lilly Corporate Center, 46285, Indiana, Indianapolis, USA

    David E. Seitz, Thomas R. Haynes & Robert L. Wolen

  3. Section of Hematology/Oncology, Arizona Cancer Center, University of Arizona College of Medicine, 85724, Tucson, Arizona, USA

    David S. Alberts & Charles W. Taylor

  4. Royal Marsden Hospital, Fulham Road, SW3 6JJ, London, UK

    Eve Wiltshaw, Janet Hardy & Mary O'Brien

Authors
  1. Frank V. Fossella
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  2. Scott M. Lippman
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  3. David E. Seitz
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  4. David S. Alberts
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  5. Charles W. Taylor
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  6. Eve Wiltshaw
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  7. Janet Hardy
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  8. Mary O'Brien
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  9. Thomas R. Haynes
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  10. Robert L. Wolen
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Additional information

Address for offprints: Department of Medical Oncology, M.D. Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX, 77030, USA

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Fossella, F.V., Lippman, S.M., Seitz, D.E. et al. Hypoprothrombinemia from coadministration of sulofenur (LY 186641) and warfarin: Report of three cases. Invest New Drugs 9, 357–359 (1991). https://doi.org/10.1007/BF00183581

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  • DOI: https://doi.org/10.1007/BF00183581

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