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The glomerular mesangium: capillary support function and its failure under experimental conditions

  • Guest Lecture, “Gesellschaft für Nephrologie”, 23rd Congress
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Summary

We present a structural analysis of the ability of the biomechanical unit consisting of mesangium and glomerular basement membrane to maintain normal capillary architecture in the face of mechanical challenges due to high intraglomerular pressures. Capillary support function may be considered in terms of the stabilization of local form (development of wall tension against capillary dilation) and global form (centripetal fixation of capillary loops to maintain higher order form). The pathologic consequences of the loss of this support are illustrated by way of experimental models of mechanical mesangial failure. Such failure may express itself as mesangial widening, increased transmesangial macromolecule “traffic,” ballooning of capillary segments, and unfolding of capillary loops. Mechanisms are described by which these structural changes may lead to segmental glomerular sclerosis.

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Author notes

  1. K. V. Lemley

    Present address: Department of Physiology, West Virginia University School of Medicine, 26506, Morgantown, WV, USA

Authors and Affiliations

  1. Institut für Anatomic und Zellbiologie I, Universität Heidelberg, Im Neuenheimer Feld 307, W-6900, Heidelberg, Germany

    K. V. Lemley, M. Elger, I. Koeppen-Hagemann, M. Kretzler, M. Nagata, T. Sakai, S. Uiker & W. Kriz

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  1. K. V. Lemley
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  2. M. Elger
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  3. I. Koeppen-Hagemann
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  4. M. Kretzler
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  5. M. Nagata
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  6. T. Sakai
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  7. S. Uiker
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  8. W. Kriz
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Lemley, K.V., Elger, M., Koeppen-Hagemann, I. et al. The glomerular mesangium: capillary support function and its failure under experimental conditions. Clin Investig 70, 843–856 (1992). https://doi.org/10.1007/BF00180755

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  • DOI: https://doi.org/10.1007/BF00180755

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