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Current status of HLA matching in renal transplantation

  • Guest Lecture, “Gesellscheff fürNephrologie”, 23rd Congress
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Summary

The impact of HLA compatibility on the success rate of kidney transplants was studied in over 80,000 recipients of primary transplants. The transplants were done from 1982 to 1991 at over 300 transplant centers in 43 countries. The results show that matching the HLA chromosomes in related donor transplants has a striking influence. It is also important that matching for individual HLA antigens in cadaver transplants provides a highly significant improvement in graft survival (P<0.0001). After 5 years, matched grafts have a survival rate approximately 20% higher than completely mismatched grafts. The matching effect is particularly strong in presensitized and second graft recipients. There is now direct evidence that even if it is necessary to transport well-matched kidneys a long way, they have a significantly higher success rate than locally transplanted poorly matched kidneys. New data based on molecular technology show that the precise identification of HLA-DR antigens by DNA typing further improves the success rate of HLA-matched transplants.

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Abbreviations

MM:

mismatched antigens

RFLP:

restriction fragment length polymorphism

References

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Authors and Affiliations

  1. Abteilung für Transplantationsimmunologie, Institut für Immunologie, Universität Heidelberg, Germany

    G. Opelz, J. Mytilineos, T. Wujciak & V. Schwarz

  2. Institut für Immunologie, Universität Heidelberg, Im Neuenheimer Feld 305, W-6900, Heidelberg, Germany

    G. Opelz

Authors
  1. G. Opelz
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  2. J. Mytilineos
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  3. T. Wujciak
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  4. V. Schwarz
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D. Back for the Collaborative Transplant Study

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Opelz, G., Mytilineos, J., Wujciak, T. et al. Current status of HLA matching in renal transplantation. Clin Investig 70, 767–772 (1992). https://doi.org/10.1007/BF00180746

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  • DOI: https://doi.org/10.1007/BF00180746

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