The clinical investigator

, Volume 70, Issue 9, pp 740–747 | Cite as

Esophageal dysfunction in diabetes mellitus: is there a relation to clinical manifestation of neuropathy?

  • D. Hüppe
  • M. Tegenthoff
  • J. Faig
  • F. Brunke
  • S. Depka
  • M. Stuhldreier
  • G. Micklefield
  • A. Gillissen
  • B. May
Original Article


In a prospective study, we evaluated 33 diabetic patients [type I (n = 8) and type II (n = 25)]. Esophageal motor functions were examined by registering clinical symptoms and by performing esophageal manometry. We also investigated peripheral and autonomic neuropathy. In diabetics, the lower and upper esophageal sphincter pressure and amplitudes of peristaltic waves were reduced. Compared with controls (n = 30), in diabetics the esophageal peristaltic velocity was reduced significantly, and the duration of contractions were decreased as well. Multipeaked waves were uncommon in diabetics, while non-propulsive contractions were seen more often. No correlation was found between esophageal dysfunction and peripheral or autonomic neuropathy. Some 60% of diabetics reported esophageal symptoms; however, no relationship between these symptoms and the extent of dysfunction in esophageal motility was found.

Key words

Diabetes mellitus Esophageal motility Manometry Autonomic cardiac neuropathy Peripheral sensorimotor neuropathy 



peripheral sensorimotor polyneuropathy


autonomic cardiac neuropathy


lower esophageal sphincter


upper esophageal sphincter






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Copyright information

© Springer-Verlag 1992

Authors and Affiliations

  • D. Hüppe
    • 1
  • M. Tegenthoff
    • 2
  • J. Faig
    • 2
  • F. Brunke
    • 1
  • S. Depka
    • 1
  • M. Stuhldreier
    • 1
  • G. Micklefield
    • 1
  • A. Gillissen
    • 1
  • B. May
    • 1
  1. 1.Abteilung für Gastroenterologie und HepatologieGermany
  2. 2.Neurologische Universitätsklinik und Poliklinik, Berufsgenossenschaftliche Krankenanstalten Bergmannsheil Bochum Universitätsklinik BochumGermany

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