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Cancer of the Esophagus: The Wayne State University experience

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Summary

The rationale for the preoperative therapy for cancer of the esophagus is described. The first trial with infusion FUra mitomycin-c and radiation performed at Wayne State University (WSU) is described. The dramatic responses were duplicated when cisplatin was substituted for mitomycin. Moreover, survival was improved over the mitomycin-c trial. These neoadjuvant trials led to a third WSU clinical trial in which the neoadjuvant therapy became the definitive therapy.

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Authors and Affiliations

  1. University Southern California, Los Angeles, California, USA

    Lawrence Leichman (Associate Professor, Medicine)

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  1. Lawrence Leichman
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Kenneth Norris Jr., Rm 162, 1441 Eastlake Ave, Los Angeles, CA 90033, USA

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Leichman, L. Cancer of the Esophagus: The Wayne State University experience. Invest New Drugs 7, 91–100 (1989). https://doi.org/10.1007/BF00178195

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