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Phase II evaluation of fludarabine phosphate in patients with central nervous system tumors

A Southwest Oncology Group trial

  • Clinical Studies
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Summary

Twenty-three patients with malignant central nervous system tumors were treated with fludarabine phosphate (2-FAMP) on a 5 day bolus schedule. One brief partial response was observed in 20 malignant astrocytoma patients. 2FAMP as given in this protocol is inactive in previously treated patients with recurrent malignant astrocytomas.

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References

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Authors and Affiliations

  1. University of Kansas Medical Center, Kansas City, KS, USA

    Sarah A. Taylor

  2. Southwest Oncology Group Statistical Center, Seattle, WA, USA

    John Crowley

  3. Duke University Medical Center, Dunham, NC, USA

    F. Stephen Vogel

  4. VA Medical Center, Salt Lake City, Utah, USA

    Jeannette J. Townsend

  5. University of Utah Medical Center, Salt Lake City, UT, USA

    Harmon J. Eyre & Kurt A. Jaeckle

  6. Wichita CCOP, Wichita, KS, USA

    Harry E. Hynes

  7. Columbus CCOP, Columbus, OH, USA

    Jerry T. Guy

Authors
  1. Sarah A. Taylor
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  2. John Crowley
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  3. F. Stephen Vogel
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  4. Jeannette J. Townsend
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  5. Harmon J. Eyre
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  6. Kurt A. Jaeckle
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  7. Harry E. Hynes
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  8. Jerry T. Guy
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Taylor, S.A., Crowley, J., Vogel, F.S. et al. Phase II evaluation of fludarabine phosphate in patients with central nervous system tumors. Invest New Drugs 9, 195–197 (1991). https://doi.org/10.1007/BF00175089

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  • DOI: https://doi.org/10.1007/BF00175089

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