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The activity of flavone acetic acid (NSC 347512) on human colon cancer cells in vitro

  • Preclinical Studies
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Abstract

Flavone acetic acid (FAA) was incubated for 1 to 48 hr with 3 established human colon cancer cell lines endowed with distinct degrees of phenotypic properties. All 3 lines responded to FAA in almost identical fashion; when incubated with the drug for only 1 hr, an initial decrease in survival was observed for concentrations of 250 μg/ml but no further increments in cytotoxicity were elicited when the concentration of FAA was augmented. Increasing the length of treatment yielded relatively modest increments (about 1 log) in cell killing only after an interval of 48 hr and only at the highest concentration (1000 μg/ml). Because of these relatively poor cytotoxic effects and because the therapeutic range of FAA is so narrow, we conclude that this agent will not be a valuable contribution to the antitumor arsenal, at least for colon cancer.

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Authors and Affiliations

  1. Division of Laboratory Medicine, University of Texas System Cancer Center, M.D. Anderson Hospital & Tumor Institute at Houston, 6723 Bertner Avenue, Box No. 73, 77030, Houston, TX, USA

    B. Drewinko M.D., Ph.D. (Professor and Chief) & L. -Y. Yang

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  1. B. Drewinko M.D., Ph.D.
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  2. L. -Y. Yang
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Drewinko, B., Yang, L.Y. The activity of flavone acetic acid (NSC 347512) on human colon cancer cells in vitro. Invest New Drugs 4, 289–293 (1986). https://doi.org/10.1007/BF00173501

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