Summary
The National Cancer Institute of Canada (NCIC) Clinical Trials Group has carried out a phase II study of acivicin given as a 72-hour continuous infusion in previously untreated patients with measurable metastatic colorectal carcinoma. Toxicity in 24 patients was mild to moderate and consisted primarily of GI symptoms such as nausea, vomiting, diarrhea or CNS changes including drowsiness, lethargy, dizziness. No responses were seen in 23 evaluable patients. We did not find acivicin given as described to be effective in colorectal carcinoma.
Similar content being viewed by others
References
Houchens DP, Ovejera AA, Sheridan MA, Johnson RK, Bogden AE, Neil GL: Therapy for mouse tumors and human tumor xenografts with the antitumor antibiotic AT-125. Cancer Treat Rep 63:473–476, 1979
O'Dwyer PJ, Alonso MT, Leyland-Jones B: Acivicin: A new glutamine antagonist in clinical trials. J Clin Oncol 2:1064–1071, 1984
Earhart RH, Koeller JM, Davis TE, Borden EC, McGovren JP, Davis HL, Tormey DC: Phase I trial and pharmacokinetics of acivicin administered by 72-hour infusion. Cancer Treat Rep 67:683–692, 1983
Weiss GR, McGovren JP, Schade D, Kufe DW: Phase I and pharmacological study of acivicin by 24-hour continuous infusion. Cancer Res 42:3892–3895, 1982
Sridhar KS, Ohnuma T, Chahinian AP, Holland JF: Phase I study of acivicin in patients with advanced cancer. Cancer Treat Rep 67: 701–703, 1983
Maroun JA, Fields AL, Pater JL, Stewart DM, Cripps C, Eisenhauer E: Phase II study of acivicin in colorectal carcinoma. A National Cancer Institute of Canada Study. Cancer Treat Rep 68:1121–1123, 1984
Etheridge B, Vonhoff D: Activity of one hour and continuous exposure of acivicin in a human tumor cloning system. Proc Amer Soc Clin Oncol (Abstr) 4:30, 1985
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Eisenhauer, E.A., Maroun, J.A., Fields, A.L. et al. Phase II study of acivicin as a 72-hr continuous infusion in patients with untreated colorectal cancer. A National Cancer Institute of Canada clinical trials group study. Invest New Drugs 5, 375–378 (1987). https://doi.org/10.1007/BF00169978
Issue Date:
DOI: https://doi.org/10.1007/BF00169978