Abstract
DNA methylation of human class II genes of the Major Histocompatibility Complex (MHC) was correlated with gene expression and methyl-related CG → TG and CG → CA changes. It was found that cytosine methylation of the CG dinucleotides of MHC class II genes should be involved in generating a fraction of nucleotide polymorphism, rather than in controlling transcription.
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Gambari, R., Piva, R., Volinia, S. et al. CG Dinucleotides of class II MHC genes are mutation hot-spots. Cytotechnology 1, 133–138 (1988). https://doi.org/10.1007/BF00146813
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DOI: https://doi.org/10.1007/BF00146813