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Successful Limb Salvage in a Case of Advanced Long-Standing Eumycetoma of the Foot Using Adjunctive Local Amphotericin B Delivery Through Bioabsorbable Beads

Abstract

Mycetoma is a chronic, granulomatous infection mainly involving the foot and is caused either by bacteria (actinomycetoma) or fungi (eumycetoma). Eumycetoma is notoriously resistant, posing a therapeutic challenge. There are no specific treatment guidelines but generally a combination of systemic antifungals and local surgical treatment is the accepted standard. Advanced unresponsive lesions generally require amputation. We present a case of eumycetoma of 15-year duration with extensive involvement of foot including bones. Patient had been advised amputation from various tertiary care centers but we decided to give a limb salvage trial. The patient underwent soft tissue debridement along with oral antifungal therapy. Additionally, amphotericin B-impregnated bioabsorbable beads were inserted locally into the bony cavities to supplement the treatment. There has been no recurrence till date. This case is reported in view of successful limb salvage in an advanced eumycetoma case with an unprecedented use of adjunctive local antifungal delivery.

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Author information

Concepts: RL, Design: RL, BVS, PD’, Definition of intellectual content: RL, BVS, PD’, Literature search: BVS, HCG, Clinical studies: BVS, HCG, Manuscript preparation: BVS, HCG, Manuscript editing: RL, BVS, HCG, Manuscript review: RL, PD’, Guarantor: RL, BVS.

Correspondence to Bhavya V. Salvi.

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Lalchandani, R., Salvi, B.V., D’souza, P. et al. Successful Limb Salvage in a Case of Advanced Long-Standing Eumycetoma of the Foot Using Adjunctive Local Amphotericin B Delivery Through Bioabsorbable Beads. JOIO (2020). https://doi.org/10.1007/s43465-019-00031-3

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Keywords

  • Eumycetoma
  • Madura foot
  • Amphotericin B
  • Bioabsorbable beads