3D-Printed Scaffolds with Reinforced Poly (Lactic Acid)/Carbon Nanotube Filaments Based on Melt Extrusion

  • Hye-Been Kim
  • Dinesh K. Patel
  • Yu-Ri Seo
  • Ki-Taek LimEmail author
Original Article


Personalized medicine suitable for individual patients in tissue engineering is a significant challenge. Owing to the recent growth of 3D printing, various methods of building objects have been proposed. However, there is very little information about the mechanical properties of the pieces obtained by controlling the process variables using composite filaments. Fused deposition modeling (FDM) technology was used to fabricate new scaffolds with infill patterns, interconnected channel networks, controllable porosity, and size. Polylactic acid (PLA)/carbon nanotube (CNT) filaments were synthesized using the melt extrusion technique. An improvement in the mechanical properties was observed in composites compared with the pure polymer. Moreover, no toxicity was expressed by stem cells after 24 h of incubation in the presence of composite filaments for a high CNT concentration. Our results will aid in the scaffold design of composite filaments through the modeling of process parameters and mechanical properties.


Polylactic acid Melt extrusion Mechanical properties 3D printing 



This research was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF), funded by the Ministry of Education (No. 2018R1A6A1A03025582) and the National Research Foundation of Korea (NRF-2016R1D1 A3B03932921).

Compliance with Ethical Standards

All protocols for human tissue processing were developed in accordance with the legal regulatory guidelines for human tissues and organs in the experimental protocol approved by the Seoul National University (Seoul, South Korea) Institutional Review Board (IRB No. CRI05008)

Conflict of Interest

The authors declare that they have no conflict of interest.

Supplementary material

42853_2019_11_MOESM1_ESM.docx (331 kb)
ESM 1 (DOCX 331 kb)


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Copyright information

© The Korean Society for Agricultural Machinery 2019

Authors and Affiliations

  • Hye-Been Kim
    • 1
  • Dinesh K. Patel
    • 2
  • Yu-Ri Seo
    • 1
  • Ki-Taek Lim
    • 1
    • 2
    Email author
  1. 1.Department of Biosystems Engineering, College of Agriculture and Life SciencesKangwon National UniversityChuncheonRepublic of Korea
  2. 2.The Institute of Forest ScienceKangwon National UniversityChuncheonRepublic of Korea

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