The first report of colistin–carbapenem resistance in Klebsiella pneumoniae ST70 isolated from the pediatric unit in India

  • Rajesh Kumar Sahoo
  • Aradhana Das
  • Saubhagini Sahoo
  • Mahendra Gaur
  • E. Venkata Rao
  • Enketeswara SubudhiEmail author
Letter to the Editor

To the Editor

Carbapenem-resistant Klebsiella pneumoniae (CRKP), which are also usually resistant to multiple antibiotics, constitute one of the main members of Enterobacteriaceae family associated with infections in humans [1, 2]. The rapid emergence of CRKP has compelled to resort back to colistin, the last line of antibiotic. However, recent occurrence of resistance in CRKP to this last resort drug leaves with no option for treatment [3]. Earlier reports described the mutation in the two-component regulatory system (mgrB, PmrAB, and PhoPQ) which is responsible for the manifestation of colistin resistance in clinical isolates [4]. Moreover, mutations in the mgrB gene, which negatively regulate PhoPQ signaling, have also been known to be responsible for acquired resistance to colistin [4]. In the present investigation, we identified Klebsiella pneumoniae RK1 from the urine sample of a 7-year-old boy who suffered urinary tract infection from the Pediatrics Department, SUM Hospital,...



The authors are thankful to Dr. NK Debata, Department of Microbiology, IMS and SUM Hospital, Siksha ‘O’ Anusandhan (deemed to be University), Bhubaneswar, Odisha, India, for providing bacterial samples and related information. The authors are also grateful to Prof (Dr.) SC Si, Dean, Centre for Biotechnology and Prof (Dr.) MR Nayak, President, Siksha ‘O’ Anusandhan University, for providing infrastructure and encouragement throughout.

Funding information

This work is supported by the Science and Engineering Research Board (EMR/2016/006732), New Delhi, India.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.


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Copyright information

© Sociedade Brasileira de Microbiologia 2019

Authors and Affiliations

  • Rajesh Kumar Sahoo
    • 1
  • Aradhana Das
    • 1
  • Saubhagini Sahoo
    • 1
  • Mahendra Gaur
    • 1
  • E. Venkata Rao
    • 2
  • Enketeswara Subudhi
    • 1
    Email author
  1. 1.Centre for BiotechnologySiksha O AnusandhanBhubaneswarIndia
  2. 2.Department of Community Medicine, IMS and SUM HospitalSiksha O AnusandhanBhubaneswaraIndia

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