China Population and Development Studies

, Volume 3, Issue 1, pp 37–52 | Cite as

The effects of parental relationships, and gender and grade differences on depressive disorder in Chinese adolescents: the evidence from multiple cross-sectional surveys (1999–2016)

  • Limin WangEmail author
  • Yafeng Zhang
  • Hui Yin
  • Zuoming Zhang
  • Yuchun Tao
  • Ye Xu
  • Lu Chen
  • Yongqing Feng
  • Yixin Liu
Open Access
Original Article


This study aims to investigate the impacts of parental relationships, gender, and grade differences on depressive disorder among Chinese adolescents over a time period of nearly 20 years. The first survey took place in 1999 and involved 852 students; subsequent follow-up surveys took place in 2006, 2009 and 2016, with 3345 students involved in total. Depressive disorder was measured by SCL-90-R (Chinese version). The surveys also collected social-demographic information about the respondents. Three indicators of parental relationships were examined—parental quarrels, parental disharmony and parental divorce. The results show that gender was significantly associated with adolescents’ depressive disorder and that there was a higher prevalence of depressive disorder among senior middle school students than among junior middle school students, except in 1999. Troubled parental relationships were associated with high risks of depressive disorder. Coefficients and 95% CI were adjusted for the survey years (1999, 2006, 2009, 2016), school grades (junior or senior middle school students), gender (girls/boys), parental quarrels (yes/no), parental disharmony (yes/no), and parental divorce (yes/no). Logistic regression indicated that parental divorce and gender were the two strongest predictors of the presence of depressive disorder. In summary, there was a higher prevalence of depressive disorder among girls and senior middle school students. Adolescents are vulnerable to depressive disorder in cases of parental divorce. Therefore, good parental relationships may be considered an important and necessary factor that affects the susceptibility of Chinese adolescents to depressive disorder.


Depressive disorder Parental relationships Gender difference Chinese adolescents 

1 Introduction

Depression is a common mental and psychological illness worldwide, one that often begins in adolescence (Demir et al. 2011; Gabbay et al. 2009; Zhou et al. 2018). Depression is a risk factor for a range of diseases and poor health outcomes (Malhotra et al. 2010). Different from other emotional reactions, students who have been depressed for a long time suffer great distress that seriously affects their lives and health, and may even lead to suicide (Subin et al. 2015). According to the World Health Organization, depression is the third leading cause of adolescent death (WHO, 2012). Furthermore, depression is the leading cause of disability worldwide and is a major contributor to the overall global burden of disease (Zheng et al. 2016). Adolescent depression is associated with a range of adverse later outcomes including suicidality, problems in social functioning, and poor physical and mental health (Anita et al. 2012; Maughan et al. 2013). One study found that the prevalence of depressive symptoms among adolescents is 16.7% in China (Zhou et al. 2018). Estimates of 1-year prevalence rates for unipolar depression in preadolescents range from 4 to 5%, while the cumulative probability of depression by the end of adolescence appears to be as high as 20% (Costello et al. 2006; Magklara et al. 2015). A recent study suggests that the total prevalence of depressive symptoms among Chinese left-behind children is 24.8% (Wang et al. 2015). However, most studies are based on data from regional surveys using different measures of depressive symptoms, and this makes it impossible to reach consistent conclusions (Pan et al. 2008). Regardless, depression disorders in puberty have become an important issue of concern worldwide. The subscale of Symptom Checklist-90-Revision (SCL-90-R) is a self-report scale to measure depressive disorders of adolescents. Unlike other scales, SCL-90-R only assesses the possibility of adolescents having a psychological disorder. The present investigation began in 1999; the scale was widely used to assess Chinese students at that time and was verified with good validity and reliability. This study investigates changes in the prevalence of depressive disorder among adolescents in a district of Harbin city over 20 years.

Another aim of the present study is to investigate gender and grade differences for adolecent depressive disorder in the region, using longitudinal data covering nearly 20 years. Individuals with high levels of depression often show low moods, loss of interest and pleasure, and reduced energy, as well as other negative symptoms such as anxiety, and sleep and appetite disorders (Derogatis et al. 1973). Research found that the lack of an intimate relationship is a risk factor for depression in the presence of vulnerability, as shown by low self-esteem of many adolescents (Aro 1994). The strongest risk factors for depression in adolescents are a family history of depression and exposure to psychosocial stress (Anita et al. 2012). Accordingly, depressive disorder is a mental illness commonly seen in puberty. Three studies from Greece documented an increasing trend in the prevalence of depression from 3.3% in 2008, to 6.8% in 2009 and 8.2% in 2011 (Skapinakis et al. 2013). Young age is identified as a relative factors for major depression in the Greek population (Economou et al. 2013). Furthermore, prevalence rates for depressive disorders increase significantly in adolecents, and gender differences emerge as well (Hankin and Abramson 1999; Ge et al. 2001). The emergence of a gender difference (more girls depressed than boys) with respect to depressed moods and depressive disorders becomes apparent after the age of 13 years or during midpuberty (Hankin and Abramson 1999). Since 1999, a series of policies related to the mental health of middle school students have been issued in China, indicating that the physical and psychological health of students have become matters of wide public concern. Consequently, there is a need to evaluate the development of policies to ensure they help to prevent depression disorder in an effective, timely manner.

Besides the correlation of age and gender factors with depressive disorder, some family factors are also important. A recent study revealed that family socioeconomic status (SES) and psychological attributes related to vulnerability to life events and coping skills were associated with depressive symptoms (Piccinelli and Wilkinson 2000; Zhou et al. 2018). In addition, children exposed to violence at home (witnessing violence against the mother and/or being the victims of parental violence themselves) are more likely to suffer from depression and affective disorders (Amato 2010, 2001; Izaguirre and Calvete 2018). Conversely, parental involvement and warmth have the potential to reduce the onset of depression (Kuo et al. 2019; Quach et al. 2015). Family interventions are a developmentally appropriate approach for preventing depression among adolescents (Kuo et al. 2019). Although previous studies have discussed the association of parent–child relationships with depressive disorders in adolescents, studies that examine this from the perspective of different culture backgrounds are few, and longitudinal tracking studies are relatively scarce, a scarcity that is exacerbated by China’s divorce rate in the twenty first century.

2 Data source and method

2.1 Survey design

This is a multiple cross-sectional study. The current study is based on survey data from the years 1999, 2006, 2009 and 2016. According to the criteria of sampling, 852 students participated in the survey in 1999, 722 students in 2006, 789 students in 2009, and 982 students in 2016 (see Table 1). The baseline survey was conducted in 1999 because a series of programmatic document related to school mental-health education was issued by the ministry of education, which means society began to pay more attention to the mental health of adolescents. Due to the reform of secondary education and the lack of research funds, the second data survey was conducted in 2006. A new set of cross-sectional data was collected in 2009 for a 10-year cross-sectional comparison with 1999. Similarly, the 2016 survey was a 10-year comparison based on 2006. The overall response rate was 97.21% among the adolescents who were present in the classrooms during the survey. All 3345 participants (aged 12–20 years) were middle school students (52.2% girls; 47.8% boys). The 3345 middle school students were required to provide demographic information including evaluations of parental relationships and to complete a self-report questionnaire: the Chinese Symptom Checklist-90-Revision (SCL-90-R). We adopted the field survey method to conduct standardized, unified questionnaire surveys on the selected research objects. Four schools were selected in a district of Harbin city, China, using a multistage sampling method (stratified random cluster) in which each school was considered as a stratum and each grade as a cluster. In the first stage, two of the four schools involved were key schools and two were common schools. In the second stage, two classes were selected as units from each grade (grades 7, 8, 10 and 11) in the selected school and the respondents were selected. Grade 9 students were excluded because they were preparing for entrance examinations. In the last stage, those respondents who refused to participate in the questionnaire survey and those who were absent when the questionnaire was administered were excluded.
Table 1

Demographic characteristics of subjects in different survey years


1999 (N = 852)

2006 (N = 722)

2009 (N = 789)

2016 (N = 982)



452 (53.1%)

332 (54.0%)

323 (40.9%)

492 (50.1%)


400 (46.9%)

390 (46.0%)

466 (59.1%)

490 (49.9%)



388 (45.5%)

340 (47.1%)

358 (45.4%)

446 (45.4%)


464 (54.5%)

382 (52.9%)

431 (54.6%)

536 (54.6%)


1.79 ± 0.64

1.88 ± 0.68

1.83 ± 0.67

1.73 ± 0.72***


54 (6.3%)

57 (7.9%)

45 (5.7%)

79 (8.0%)


98 (11.5%)

47 (6.5%)

86 (10.9%)

92 (9.4%)

No quarrels

754 (88.5%)

675 (93.5%)

703 (89.1%)

890 (90.6%)


733 (86.0%)

621 (86.0%)

680 (86.2%)

863 (87.9%)


119 (14.0%)

101 (14.0%)

109 (13.8%)

119 (12.1%)


33 (3.9%)

44 (6.1%)

39 (4.9%)

108 (10.9%)

No divorce

819 (96.1%)

678 (93.9%)

750 (95.1%)

874 (89.1%)

Column categorical data present shown as n (%); continuous data shown as mean ± SD. DS shown as depression score. PD shown as prevalence rates of depressive disorder. Pearson Chi square was determined from categorical data. Wilcoxon rank sum test for continuous variables

*p < 0.05. **p < 0.01. ***p < 0.001 statistical significance, comparison between four different survey years

2.2 Survey procedure

With the assistance of head teachers, information was collected from the adolescents who completed an anonymous, structured, self-report questionnaire in the classroom. When the questionnaire was completed, it was collected on-site. We required qualified interviewees to cooperate and answer the questionnaire truthfully to ensure authenticity and effectiveness. The data collection was conducted by professionally trained graduate students. The interviewers were as familiar with the questionnaire as possible and had mastered some interview and communication techniques to allow them to effectively answer the questions of the adolescents. Researchers explained to the participants the purpose of the investigation and assured participants that the information they provided was confidential, and that the interviews took an average of 40 min. We sought permission from each school and the participants’ informed verbal consent. Questionnaires, procedures, consent forms, and instructions were reviewed by the Ethics Committee of the Harbin Medical University.

2.3 Measurement

The 13 items on the depression subscale derived from the Symptom Checklist-90-Revision (SCL-90-R) were used to assess adolescent depressive disorders (Derogatis et al. 1973). The depression subscale evaluates depressed emotions and moods during the 2 weeks prior to taking the survey as representative symptoms. The subscale rates on a 5-point Likert-type scale (1 = never; 5 = very frequently), with higher scores indicating higher levels of depressive disorder. The depression subscale consisted of 13 questions. Participants were invited to rate all depression items. The average score of depressive disorder was produced by dividing the total score of each participant by 13. Of note, the scale assesses the presence and severity of depressive disorder, with more than 3 points that can serve as cutoff points for defining the prevalence of depressive disorder (Zhang 2005). In 1999, Chinese scholars tested the reliability and validity of the SCL-90-R and established norms for middle school students in Beijing, demonstrating that SCL-90-R is a measurement tool suitable for middle school students (Jisheng et al. 1999). The standard Center for Epidemiological Studies Depression Scale (CES-D) was used to test the criterion-related validation of the depression subscale in our study. It was found that there was a significant positive correlation between the two scales (Spearman’s rho = 0.72). The depression subscale of SCL-90-R was found to have good internal consistency and reliability (Cronbach’s alpha = 0.97). The reliability of SCL-90-R in the surveys at four-time points (1999, 2006, 2009, and 2016) was 0.95, 0.96, 0.96 and 0.96, respectively. Alpha coefficients for depression sub-scales at four-time points were found to be 0.89, 0.91, 0.93 and 0.91, respectively.

Parental relationship factors consist of parental quarrels, parental disharmony and parental divorce, and are measured based on the adolescent’s subjective evaluation. Answers self-reported by adolescents to these questions “Do your parents often quarrels with each other?” (response is “yes” or “no”), “Is there harmony between your parents?” (response is “yes” or “no”), and “Are your parents divorced?” (response is “yes” or “no”) are recorded. It’s worth noting that parental quarrels refers to the frequent verbal arguments and excessive verbal behaviors between parents, while parental disharmony means that parents do not communicate verbally and feel indifferent to each other. In addition, other demographic information such as gender, grade and age of the adolescents are also obtained.

2.4 Statistical analysis

Socio-demographic characteristics are determined through the use of descriptive statistical analysis. The prevalence of depressive disorders in different survey years, and grades, as well as prevalence based on gender and prevalence connected to parental relationships are calculated with cross-tabulations. Odds ratios and 95% confidence intervals are calculated to estimate the effect of different parental relationships on depression disorder. Then the normality test and rank-sum test are used to determine the significance of differences between different survey years. Continuous variables were evaluated using the Wilcoxon rank sum test, and categorical variables were assessed with the Chi squared test. Binary logistic regression was performed to determine the independent association of parental quarrels, parental disharmony, and parental divorce with depressive disorder. The fixed model used indicator variables including survey years, gender, and grade as control variables. Independent variables and control variables were then forced into logistic regression analysis to adjust for the association of depressive disorder. SPSS software (version 21.0) was used for statistical analyses. A p value of less than 0.05 indicates statistical significance.

3 Results

Table 1 displays the demographic variables, depressive scores, the prevalence of depressive disorder and adolescents’ parental relationships (parenal quarrels, disharmony and divorce) for the four surveys. A total of 3345 adolescents participated, with girls accounting for 52.2% and boys for 47.8%. The mean age of the adolescents was approximately 15 years old. As for the individual surveys, significant difference in depressive score were observed for the four survey years (in 1999, 1.79 ± 0.64; in 2006, 1.88 ± 0.68; in 2009, 1.83 ± 0.67; in 2016, 1.73 ± 0.72, P<0.001). The prevalence of depressive disorder fluctuated from 5.7% to 8.0% over the survey years. Parental relationships consist of parental quarrels, parental disharmony and parental divorce. In terms of parental quarrels, the prevalences were 11.5% in 1999, 6.5% in 2006, 10.9% in 2009 and 9.4% in 2016. The average for parental disharmony in the study sample was greater than 10%. Furthermore, the percentage of parental divorce reached 10.9% in 2016 and this was significantly higher than in the other survey years.

Regarding gender and grade, the percentage of girls with depressive disorder was significantly higher than the percentage of boys. And except for the baseline survey, more senior middle school students had depressive disorders than junior middle school students (Table 2). Prevalence and odds ratio of depressive disorders related to parental relationships was also reported (Table 3). Of particular note is the fact that participants were at higher risk of depressive disorder for parental quarrels and disharmony in 2009 [OR: 2.89 (1.40–5.93); OR: 3.09 (1.58–6.01)], and for parental divorce in 2016 [OR: 3.14 (1.81–5.46)].
Table 2

The prevalence of depressive disorder depression among different subgroups by grade and gender






Gender a



23 (5.1%)

19 (5.7%)

10 (3.1%)

38 (7.7%)**


31 (7.8%)

38 (9.7%)

35 (7.5%)

41 (8.4%)

Grade b



30 (7.7%)

24 (7.1%)

17 (4.7%)

28 (6.3%)


24 (5.2%)

33 (8.6%)

28 (6.5%)

51 (9.5%)

Categorical data shown as n (%). Pearson Chi squared was determined from categorical data

Gendera compared boys with girls. Gradeb compared junior with senior

*p < 0.05. **p < <0.01. ***p < <0.001 statistical significance

Table 3

Prevalence and odds ratio of depressive disorder by parental relationships (%)

Survey years


No depressive disorder

Depressive disorder


95% CI




No parental quarrels

709 (94.0)

45 (6.0)





Parental quarrels

89 (90.8)

9 (9.2)


Parental harmony

690 (94.1)

43 (5.9)





Parental disharmony

108 (90.8)

11 (9.2)


No parental divorce

767 (93.7)

52 (6.3)





Parental divorce

31 (93.9)

2 (6.1)



No parental quarrels

623 (92.3)

52 (7.7)





Parental quarrels

42 (89.4)

5 (10.6)


Parental harmony

572 (92.1)

49 (7.9)





Parental disharmony

93 (92.1)

8 (7.9)


No parental divorce

625 (92.2)

53 (7.8)





Parental divorce

40 (90.9)

4 (9.1)



No parental quarrels

669 (95.2)

34 (4.8)





Parental quarrels

75 (87.2)

11 (12.8)


Parental harmony

649 (95.4)

31 (4.6)





Parental disharmony

95 (87.2)

14 (12.8)


No parental divorce

710 (94.7)

40 (5.3)





Parental divorce

34 (87.2)

5 (12.8)



No parental quarrels

817 (91.8)

73 (8.2)





Parental quarrels

86 (93.5)

6 (6.5)


Parental harmony

794 (92.0)

69 (8.0)





Parental disharmony

109 (91.6)

10 (8.4)


No parental divorce

815 (93.2)

59 (6.8)**





Parental divorce

88 (81.5)

20 (18.5)


Parental quarrels refer to an adolescent’s subjective assessment of arguments at home. Parental disharmony means frequent tension in the relationship between parents. Parental divorce refers to the legal dissolution of the marriage between parents

OR odds ratio, CI confidence interval

*p < 0.05. **p < 0.01. ***p < 0.001 statistical significance

Binary logistic regression was performed to determine the relationship between gender, grades, survey years, parental quarrels, parental disharmony, and parental divorce with depressive disorder (Table 4). The results indicate that parental divorce and gender were the two strongest predictors of the presence of depressive disorder. [Parental divorce (odds ratio, 2.18; 95% confidence interval, 1.43–3.30; P < 0.001), gender (odds ratio, 0.67; 95% confidence interval, 0.51–0.88; P < 0.01] (Table 4).
Table 4

Binary logistic regression analysis of factors related to depressive disorder



95% CI

P value



Survey years










Parental quarrels





Parental disharmony





Parental divorce










OR odds ratio, CI confidence interval

4 Discussion

In terms of the depressive scores, although there are statistically significant differences between the survey years, a certain relatively low level of depression can be found among adolescents in all of the survey years. According to the SCL-90-R, overall for all of the four surveys, 5.7–8.0% of adolescents met the criteria for depressive disorders. The results also suggest that senior students and girls have a higher risk of having a depressive disorder. Parental relationships such as parental quarrels, parental disharmony and parental divorce are also associated with a higher risk of having depressive disorder. Among these, gender and parental divorce were identified as independent factors related to depressive outcomes, after controlling for demographic variables and other parental relationships.

Firstly, the results of this study show that during a time period of nearly 20 years, depressive disorders affected some adolescents in a district of Harbin city. Although some reports claim that the prevalence of depressive disorders has increased over time, in fact we found that it remained relatively stable over the entire time period. Moreover, the prevalence of depressive disorder found in this study is less than 10% overall. This is somewhat higher than the prevalence of 5.67% found in Magklara’s study, but much lower than the prevalence of 15.3% shown in He’s study and 24.8% shown in Wang’s study (He et al. 2012; Magklara et al. 2015; Wang et al. 2015). The difference of prevalence found in the present study may be a result of this study using different indicators for depressive disorder. It is worth noting that SCL-90-R is one of the most widely used measures of psychological distress in both clinical patients and community non-patients (Róbert et al. 2014). Moreover, SCL-90-R has been widely used to assess Chinese students and verified with good validity and reliability (Xin et al. 2012). Note also that the education department in the Harbin district where we conducted our study was not playing a significant role in adolescent mental health education, and this may have influenced the number of adolescents we found affected by depressive disorder. Although a series of policy documents about strengthening mental health education for students have been promulgated by the Ministry of Education, these policies have not produced satisfactory effects. Therefore, the policies set out in these documents need more effective implementation, especially with respect to the occurrence of depressive disorders among adolescents.

Secondly, the result suggest that prevalence of depressive disorder among senior students is higher than among junior students, except for the study year 1999. This may be because the division between primary school and junior middle school years was at a different place at that time. However, studies have shown differences in the prevalence of depression among different age groups, and it has been determined that adolescents have a higher rate of depression than preadolescents (Wang et al. 2015; Gau et al. 2005). Indeed, senior students face more academic pressure and burdens, and the pressures on young people in general to succeed are considerable (Hesketh and Ding 2005). Besides, as young people mature and undergo hormonal changes and emotional and cognitive development, senior students seem to encounter more serious psychological challenges and interpersonal conflicts (Aro 1994). Adolescence is a critical life stage, and problems like depression that occur during adolescence can persist into adulthood (Wilcox and Anthony 2004). Accordingly, it is necessary to pay attention to the mental health of teenagers and help them cope with academic pressure and resolve interpersonal conflicts in ways that are effective responses to depressive disorders during puberty.

Thirdly, the findings of earlier studies have shown that girls are generally more prone to depressive disorder than boys (Kendler and Gardner 2014, Parker and Brotchie 2010). Higher rates of depression in females are first detected at mid-puberty and adult women continue into adult life, while there is a preponderance of male depression during early adolescence (Piccinelli and Wilkinson 2000). The results of this study reveal that gender was found to be significantly associated with depressive disorder, and are consistent with Sloan’s results (Sloan and Sandt 2001). The interaction between psychosocial factors and physiological changes associated with adolescence may explain why there is more depressive disorder among girls than boys (Lewis et al. 2015). Parker also found that when young girls become depressed they tend to become quiet and keep to themselves, while boys are more likely to act out with anger and irritability, thus artificially inflating the rate of observed depression in boys (Parker and Brotchie 2010). Additionally, it is possible that girls have less resilience than boys or that their coping strategies are less effective and more dysfunctional than those of boys (Aro 1994). Consequently, interventions to prevent or treat adolecent depressive disorders should pay more attention to girls, especially given the nature of Chinese culture.

Our study shows that parental quarrels, disharmony and divorce are relative factors for depressive disorder. Children who have good relationships with their families are less likely to be depressed (McKinney et al. 2010). Some studies have found that the establishment and maintenance of self-esteem and self-efficacy was of central concern in depression research (Aro 1994). Garmezy concluded that family cohesion and an absence of discord were variables that operated as protective factors supporting adolescent stress resistance (Garmezy 1985). The family environment is crucial to the formation of positive mental health during puberty. Adolescents who living in an atmosphere of parental quarrels and disharmony are likely to develop a negative attitude towards interpersonal communication and form sensitivity and inferiority character traits. Support from parents also plays an important role in the ability of adolescents to overcome depressive disorders. Because parental relationships are associated with the development of depressive disorder in adolescents, preventative measures and interventions in support of positive family relationships are vital to reducing the occurrence of depressive disorder.

Finally, parental divorce is a factor that also affects depressive disorders. Brown and his colleagues have shown that lack of care is a key vulnerability factor contributing to depression (Brown et al. 1986). Di found that mother–child interaction can effectively alleviate the connections between parental divorce and depressive symptoms (Di et al. 2015). Parental divorce can also lead to loss of interest in learning, feelings of inferiority, depression, and even extreme behaviors like attempted suicide or suicide (Lizardi and Rgkeyes 2009). On the one hand, parental divorce can be very traumatic for adolescent children, not only making them feel ashamed with their peers, but also inferior. On the other hand, adolescence is a period of psychological rebellion for young people, and parental divorce may limit the involvement parents have in their children’s education, and this may result in psychological distortions on the part of the children. Reducing the occurrence of depressive disorder among adolescents will therefore need to consider measures to enhance parental relationships.

In conclusion, the different prevalence of depressive disorders among adolescents of different genders and grades can help to identify populations that could benefit from interventions. Parental relationships, especially parental divorce, are key factors contributing to the occurrence of depressive disorders among adolescents. Measures or interventions that can prevent or limit problems in parent–child relationships can help to reduce the occurrence of depressive disorders.

This study has some limitations. Firstly, the study used multiple cross-sections, precluding any causal interpretations. Secondly, the four cross-sectional surveys took at internals over a 20 year period, and we included the survey years as covariant into the model, but depressive disorders may be disturbed by social development. Thirdly, using the self-reports of adolescent respondents to describe parental relationships rather than direct interviews with parents may have resulted in some under-reporting of parental relationship issues or a failure to capture the wide range of parental relationship variations. Finally, as we noted earlier in this paper, SCL-90-R is only suited to assess psychopathological symptomatology during adolescence given its acceptable psychometric properties.



We want to thank Ms. Lin Lin for her help preparing and administering all four surveys. Thanks for the active cooperation and support from Qingxia Zhao, Pengfei Gu, Xiuzhen Ma, Chuanren Na, Guang Yang and Hong Zhu.


This study was funded by the Humanities and Social Sciences Research and Planning Fund of the Ministry of Education (grant number 15YJAZH073).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.


  1. Amato, P. R. (2001). Children of divorce in the 1990s: An update of the Amato and Keith (1991) meta-analysis. Journal of Family Psychology, 15(3), 355–370.CrossRefGoogle Scholar
  2. Amato, P. R. (2010). Research on divorce: Continuing trends and new developments. Journal of Marriage & Family, 72(3), 650–666.CrossRefGoogle Scholar
  3. Anita, T., Stephan, C., Pine, D. S., & Thapar, A. K. (2012). Depression in adolescence. The Lancet, 379, 1056–1067.CrossRefGoogle Scholar
  4. Aro, H. (1994). Risk and protective factors in depression: A developmental perspective. Acta Psychiatrica Scandinavica. Supplementum, 377, 59–64.CrossRefGoogle Scholar
  5. Brown, G., Harris, T., & Bifulco, A. (1986). Long-term effects of early loss of parent. In M. Rutter, C. Izard, & P. Read (Eds.), Depression in young people (pp. 251–296). New York: Guilford Press.Google Scholar
  6. Costello, E. J., Erkanli, A., & Angold, A. (2006). Is there an epidemic of child or adolescent depression? Journal of Child Psychology and Psychiatry, 47(12), 1263–1271.Google Scholar
  7. Demir, T., Karacetin, G., Demir, D. E., & Uysal, O. (2011). Epidemiology of depression in an urban population of Turkish children and adolescents. Journal of Affective Disorders, 134(1–3), 168–176.CrossRefGoogle Scholar
  8. Derogatis, L. R., Lipman, R. S., & Covi, L. (1973). SCL-90: an outpatient psychiatric rating scale–preliminary report. Psychopharmacology Bulletin, 9(1), 13–28.Google Scholar
  9. Di, M. L., Macdonald, J. A., & Knight, T. (2015). Erratum to “Family dissolution and offspring depression and depressive symptoms: A systematic review of moderation effects”. Journal of Affective Disorders, 188(2), 68–79.Google Scholar
  10. Economou, M., Madianos, M., Peppou, L. E., Patelakis, A., & Stefanis, C. N. (2013). Major depression in the era of economic crisis: A replication of a cross-sectional study across Greece. Journal of Affective Disorders, 145(3), 308–314.CrossRefGoogle Scholar
  11. Gabbay, V., Klein, R. G., Alonso, C. M., Babb, J. S., Nishawala, M., De, J. G., et al. (2009). Immune system dysregulation in adolescent major depressive disorder. Journal of Affective Disorders, 115(1–2), 177–182.CrossRefGoogle Scholar
  12. Garmezy, N. (1985). Stress-resistant children: The search for protective factors. In J. E. Stevenson (Ed.), Recent research in developmental psychopathology (pp. 213–233). Oxford/New York: Pergamon Press.Google Scholar
  13. Gau, S. S. F., Chong, M. Y., Chen, T. H. H., & Cheng, A. T. A. (2005). A 3-year panel study of mental disorders among adolescents in Taiwan. American Journal of Psychiatry, 162, 1344–1350.CrossRefGoogle Scholar
  14. Ge, X., Conger, R. D., & Elder, G. H. (2001). Pubertal transition, stressful life events, and the emergence of gender differences in adolescent depressive symptoms. Developmental Psychology, 37(3), 404–417.CrossRefGoogle Scholar
  15. Hankin, B. L., & Abramson, L. Y. (1999). Development of gender differences in depression: Description and possible explanations. Annals of Medicine, 31(6), 8.CrossRefGoogle Scholar
  16. He, B., Fan, J., Liu, N., Li, H., Wang, Y., Williams, J., et al. (2012). Depression risk of ‘left-behind children’ in rural China. Psychiatry Research, 200(2–3), 306–312.CrossRefGoogle Scholar
  17. Hesketh, T., & Ding, Q. J. (2005). Anxiety and depression in adolescents in urban and rural China. Psychological Reports, 96(2), 435.CrossRefGoogle Scholar
  18. Izaguirre, A., & Calvete, E. (2018). Exposure to family violence and internalizing and externalizing problems among Spanish adolescents. Violence and Victims, 33(2), 368–382.CrossRefGoogle Scholar
  19. Jisheng, W., Yan, L., & Ershi, H. (1999). Reliability and validity of the SCL-90-R and a norm of middle school students. Chinese Mental Health Journal, 13(1), 8–10. (In Chinese).Google Scholar
  20. Kendler, K. S., & Gardner, C. O. (2014). Sex differences in the pathways to major depression: A study of opposite-sex twin pairs. American Journal of Psychiatry, 171(4), 426–435.CrossRefGoogle Scholar
  21. Kuo, C., Lovette, A., Stein, D. J., Cluver, L. D., Brown, L. K., Atujuna, M., et al. (2019). Building resilient families: Developing family interventions for preventing adolescent depression and HIV in low resource settings. Transcultural Psychiatry, 56(1), 187–212.CrossRefGoogle Scholar
  22. Lewis, A. J., Kremer, P., Douglas, K., Toumborou, J. W., Hameed, M. A., Patton, G. C., et al. (2015). Gender differences in adolescent depression: Differential female susceptibility to stressors affecting family functioning. Australian Journal of Psychology, 67(3), 131–139.CrossRefGoogle Scholar
  23. Lizardi, D., & Rgkeyes, T. (2009). Parental divorce, parental depression, and gender differences in adult offspring suicide attempt. Journal of Nervous & Mental Disease, 197(12), 899–904.CrossRefGoogle Scholar
  24. Magklara, K., Bellos, S., Niakas, D., Stylianidis, S., Kolaitis, G., Mavreas, V., et al. (2015). Depression in late adolescence: A cross-sectional study in senior high schools in Greece. Bmc Psychiatry, 15(1), 199.CrossRefGoogle Scholar
  25. Malhotra, R., Chan, A., & Ostbye, T. (2010). Prevalence and correlates of clinically significant depressive symptoms among elderly people in Sri Lanka: Findings from a national survey. International Psychogeriatrics, 22(2), 227–236.CrossRefGoogle Scholar
  26. Maughan, B., Collishaw, S., & Stringaris, A. (2013). Depression in childhood and adolescence. Journal of the Canadian Academy of Child and Adolescent Psychiatry, 22(1), 35–40.Google Scholar
  27. Mckinney, C., Donnelly, R., & Renk, K. (2010). Perceived parenting, positive and negative perceptions of parents, and late adolescent emotional adjustment. Child and Adolescent Mental Health, 13(2), 66–73.CrossRefGoogle Scholar
  28. Pan, A., Franco, O., Wang, Y. F., Yu, Z. J., Ye, X. W., & Lin, X. (2008). Prevalence and geographic disparity of depressive symptoms among middle-aged and elderly in China. Journal of Affective Disorders, 105, 167–175.CrossRefGoogle Scholar
  29. Parker, G., & Brotchie, H. (2010). Gender differences in depression. International Review of Psychiatry, 22(5), 429–436.CrossRefGoogle Scholar
  30. Piccinelli, M., & Wilkinson, G. (2000). Gender differences in depression. Critical review. British Journal of Nutrition, 177(177), 486–492.Google Scholar
  31. Quach, A. S., Epstein, N. B., Riley, P. J., Falconier, M. K., & Fang, X. (2015). Effects of parental warmth and academic pressure on anxiety and depression symptoms in Chinese adolescents. Journal of Child and Family Studies, 24(1), 106–116.CrossRefGoogle Scholar
  32. Róbert, U., Bernadette, K., Judit, F., Borbála, P., Gy Ngyi, K. K. N., Zsolt, U., et al. (2014). Bifactor structural model of symptom checklists: SCL-90-R and Brief Symptom Inventory (BSI) in a non-clinical community sample. Psychiatry Research, 216, 146–154.CrossRefGoogle Scholar
  33. Skapinakis, P., Bellos, S., Koupidis, S., Grammatikopoulos, I., Theodorakis, P. N., & Mavreas, V. (2013). Prevalence and sociodemographic associations of common mental disorders in a nationally representative sample of the general population of Greece. BMC Psychiatry, 13(1), 163.CrossRefGoogle Scholar
  34. Sloan, D. M., & Sandt, A. R. (2001). Gender differences in depression. Current Directions in Psychological Science, 10(5), 173–176.CrossRefGoogle Scholar
  35. Subin, P., Ahmad, H. S., Manit, S., Sung-Man, C., Chia-Yih, L., Dianne, B., et al. (2015). The association of suicide risk with negative life events and social support according to gender in Asian patients with major depressive disorder. Psychiatry Research, 228(3), 277–282.CrossRefGoogle Scholar
  36. Wang, L., Feng, Z., Yang, G., Yang, Y., Dai, Q., Hu, C., et al. (2015). The epidemiological characteristics of depressive symptoms in the left-behind children and adolescents of Chongqing in China. Journal of Affective Disorders, 177, 36–41.CrossRefGoogle Scholar
  37. WHO. (2012). World suicide prevention day. Accessed June 16, 2012.
  38. Wilcox, H. C., & Anthony, J. C. (2004). Child and adolescent clinical features as forerunners of adult-onset major depressive disorder: retrospective evidence from an epidemiological sample. Journal of Affective Disorders, 82(1), 9–20.CrossRefGoogle Scholar
  39. Xin, Z., Zhang, M., & He, L. (2012). Changes in college students’ mental health: A crosstemporal meta-analysis. Acta Psychiatrica Scandinavica, 44, 664–679.Google Scholar
  40. Zhang, Z. J. (2005). Handbook of behavioral medical scales. Chinese journal of behavioral medical science. Beijing: Chinese Medical Multimedia Press. [In Chinese].Google Scholar
  41. Zheng, P., Zeng, B., Zhou, C., Liu, M., Fang, Z., Xu, X., et al. (2016). Gut microbiome remodeling induces depressive-like behaviors through a pathway mediated by the host’s metabolism. Molecular Psychiatry, 21(6), 786–796.CrossRefGoogle Scholar
  42. Zhou, Q., Fan, L., & Yin, Z. (2018). Association between family socioeconomic status and depressive symptoms among Chinese adolescents: Evidence from a national household survey. Psychiatry Research, 259, 81–88.CrossRefGoogle Scholar

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© China Population and Development Research 2019

This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (, which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

Authors and Affiliations

  • Limin Wang
    • 1
    Email author
  • Yafeng Zhang
    • 1
  • Hui Yin
    • 1
  • Zuoming Zhang
    • 1
  • Yuchun Tao
    • 1
  • Ye Xu
    • 2
  • Lu Chen
    • 1
  • Yongqing Feng
    • 1
  • Yixin Liu
    • 1
  1. 1.Department of Health Education, School of Public HealthHarbin Medical UniversityHarbinChina
  2. 2.Department of PsychiatricThe First Clinical Medical College of Harbin Medical UniversityHarbinChina

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