Research Center of 3D Bioprinting in Shanghai Ninth People’s Hospital
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The center was first established in 2013 and affiliated to the Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine. In 2015, the center was entitled as 3D Bioprinting Clinical Transformation Collaborative Innovation Center. In 2016, the center was renamed as Medical 3D Printing Innovation Research Center of Shanghai Jiao Tong University School of Medicine. Although the center was established in 2013, the clinical application of 3D printing in Shanghai Ninth People’s Hospital can be traced back to the 1990s. As early as 30 years ago, Prof. Kerong Dai had tried to rebuild patients pelvic by manually cutting the foam boards and layering them together based on the theory of 3D printing for preoperative planning model of abnormal skeleton structures and development of personalized prosthesis. That was the first application of 3D printing in the area of medicine in China. Now, The Research Center of 3D Bioprinting in Shanghai Ninth People’s Hospital comprised of subcenters including the outpatient department of 3D printing, medical 3D printing innovation research center and Shanghai key laboratory of orthopedic implant.
Development and transformation of 3D-printed medical application. It is to develop innovative medical devices and medical treatment modes using 3D printing technology.
Demonstration base of 3D-printed medical application. The successful clinic case of 3D-printed medical application in Shanghai Ninth People’s Hospital will be demonstrated.
Talent training base of 3D-printed medical application. There are various education-training classes, salons and international conferences held every year.
- (4)Service base of 3D-printed medical application. Scientific services were provided for other institutions (Fig. 1).
Up to now, the team led by Prof. Kerong Dai has won the second prize of National Invention Award for the development and first application of shape-memory alloy embracing device in clinical practice. Moreover, the team was nominated and acquired the second prize of National Science and Technology Progress Award for its innovative design and implantation of 3D-printed prosthesis for patients. In 2004, the group obtained the only registration license of personalized osteoarticular medical device in China.
3D-printed medical models, rehabilitation devices and surgical guides.
Designing and 3D printing of individualized metal orthopedic implant
Since 1990s, the team led by Prof. Kerong Dai has focused on using 3D printing technology to prepare individualized metal orthopedic implants (Fig. 4). Up to now, the team has successfully designed and fabricated the specialized implants for curing various tumor in pelvic, hip joint, shoulder, cervical and other parts of body. Besides, 3D-printed metal prosthesis manufactured by this team has also been used for complicated prosthesis replacement revision (such as the large area of osteolysis in acetabular wall after hip replacement), deformity of low limb and necrosis of lunate. Moreover, in addition to orthopedic, this technology has also been applied in other medical field, such as oral and maxillofacial, ophthalmology, otolaryngology. It is worth mentioning that under the instruction of Prof. Kerong Dai, the team first used memory titanium alloy to fabricate the bone fixation device worldwide and won the second prize of National Science and Technology Progress Award. Lately, the team has won the first prize of Shanghai Science and Technology Progress Award for its efforts in applying customized metal orthopedic implant in treating pelvic tumor patients.
3D bioprinting technology used for fabrication of tissue-specific, biphasic scaffolds
Multi-nozzle 3D bioprinting of bio-ink technology
The center is keeping in touch with many international research centers and research groups, including student exchange, visiting scholars and international program. They are affiliated to world famous hospitals, universities or foundations, such as Mayo Clinic, AO foundation from Switzerland, American Society for Bone and Mineral Research (ASBMR), Wyss biomedical center from Harvard Medical School, Chiba University of Japan, Georgia Institute of Technology. Other groups from international companies which focused on biomedicine, such as Johnson&Johnson Medical Ltd., Stryker Corporation, have deep communications with the center. Many of these institutions have built solid cooperation and long-term collaborations with the center.
Annually, the center will hold two international conferences. During these conferences, there are special sub-conference for the theme of 3D bioprinting and medical transformation. A latest conference named “The 8th International Conference Rehabilitation Medicine & Engineering” was held in Shanghai, and many experts in 3D bioprinting field were invited to show their achievements in 3D bioprinting.
Since 1990s, a flourishing development has been witnessed in 3D printing technology and its medical application, which was from the fabrication of in vitro medical models and surgical guides to the construction of in vivo personalized implants. In the future, 3D printing is expected to fabricate bioactive artificial organs or tissues which could be used for the regeneration and replacement of human injured tissues. Of particular note is that the successful application of 3D printing in the field of medicine relies on the multidisciplinary cooperation, involving the collaboration of experts in medicine, materials science, engineering and other fields. 3D printing has great and far-reaching significance for the development of regenerative medicine, and it is possible to fundamentally change the situation of regenerative medicine in the coming decades.
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Conflict of interest
All the authors declare that they have no conflict of interest
Human or animal rights
This article does not contain any studies with human or animal subjects performed by any of the author.