, Volume 18, Issue 3, pp 331–332 | Cite as

Mona Lisa is euthyroid: a modern-day diagnosis

  • Michael YafiEmail author
Historical Note


Making any medical diagnosis of an individual appearing in an old painting is risky. Throughout history, the famous painting of the Mona Lisa by Leonardo da Vinci has challenged many scientists and physicians to scrutinize this striking and enigmatic female image for the purpose of potentially explaining the woman “behind the smile” and offering a medical diagnosis of her state of health. A recent proposal was that she suffered from severe hypothyroidism and that her asymmetric smile was due to psychomotor retardation. Today, in the twenty-first century, can Mona Lisa get “a second opinion?”


Medical diagnosis Euthyroid Portrait 



  1. 1.
    Dequer J, Muls E, Leenders K (2004) Xanthelasma and lipoma in Leonardo da Vinci’s Mona Lisa. Isr Med Assoc J 6(8):505–506Google Scholar
  2. 2.
    Ose L (2008) The real code of Leonardo da Vinci. Curr Cardiol Rev 4(1):60–62CrossRefPubMedPubMedCentralGoogle Scholar
  3. 3.
    Maloney WJ (2011) Bell’s palsy: the answer to the riddle of Leonardo da Vinci’s “Mona Lisa”. J Dent Res 90(5):580–582. CrossRefPubMedGoogle Scholar
  4. 4.
    Ashrafan H (2016) Leonardo da Vinci’s Mona Lisa: medical differentials and primary biliary cholangitis. Acta Gastroenterol Belg 79(3):375–379Google Scholar
  5. 5.
    Mehra MR, Campbell HR (2018) The Mona Lisa decrypted: allure of an imperfect reality. Mayo Clin Proc 93(9):1325–1327CrossRefPubMedGoogle Scholar
  6. 6.
    Laios et al (2015) Goiter in ancient Greek art. Indian J Endocrinol Metab 19(1):190CrossRefPubMedPubMedCentralGoogle Scholar
  7. 7.
    Shakespeare W (1958) The Tempest. Harvard University Press, Cambridge, pp 1564–1616 PrintGoogle Scholar

Copyright information

© Hellenic Endocrine Society 2019

Authors and Affiliations

  1. 1.Division of Pediatric EndocrinologyUTHealth, The University of Texas Health Science Center in Houston/McGovern Medical SchoolHoustonUSA

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